Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria [Cell Biology]

In conclusion, macrophage autophagy protects against ALD by promoting IRF1 degradation and removal of damaged mitochondria, limiting macrophage activation and inflammation.

Source: Journal of Biological Chemistry - August 15, 2019 Category: Chemistry Authors: Shuang Liang, Zhenyu Zhong, So Yeon Kim, Ryosuke Uchiyama, Yoon Seok Roh, Hiroshi Matsushita, Roberta A. Gottlieb, Ekihiro Seki Tags: Immunology Source Type: research