Cancers, Vol. 11, Pages 1174: Use of Antibiotics and Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies

Cancers, Vol. 11, Pages 1174: Use of Antibiotics and Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies Cancers doi: 10.3390/cancers11081174 Authors: Fausto Petrelli Michele Ghidini Antonio Ghidini Gianluca Perego Mary Cabiddu Shelize Khakoo Emanuela Oggionni Chiara Abeni Jens Claus Hahne Gianluca Tomasello Alberto Zaniboni The association between antibiotic use and risk of cancer development is unclear, and clinical trials are lacking. We performed a systematic review and meta-analysis of observational studies to assess the association between antibiotic use and risk of cancer. PubMed, the Cochrane Library and EMBASE were searched from inception to 24 February 2019 for studies reporting antibiotic use and subsequent risk of cancer. We included observational studies of adult subjects with previous exposure to antibiotics and available information on incident cancer diagnoses. For each of the eligible studies, data were collected by three reviewers. Risk of cancer was pooled to provide an adjusted odds ratio (OR) with a 95% confidence interval (CI). The primary outcome was the risk of developing cancer in ever versus non-antibiotic users. Cancer risk’s association with antibiotic intake was evaluated among 7,947,270 participants (n = 25 studies). Overall, antibiotic use was an independent risk factor for cancer occurrence (OR 1.18, 95%CI 1.12–1.24, p < 0.001). The risk was especially...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research