Cancers, Vol. 11, Pages 1110: MiT Family Translocation Renal Cell Carcinoma: from the Early Descriptions to the Current Knowledge

Cancers, Vol. 11, Pages 1110: MiT Family Translocation Renal Cell Carcinoma: from the Early Descriptions to the Current Knowledge Cancers doi: 10.3390/cancers11081110 Authors: Anna Caliò Diego Segala Enrico Munari Matteo Brunelli Guido Martignoni The new category of MiT family translocation renal cell carcinoma has been included into the World Health Organization (WHO) classification in 2016. The MiT family translocation renal cell carcinoma comprises Xp11 translocation renal cell carcinoma harboring TFE3 gene fusions and t(6;11) renal cell carcinoma harboring TFEB gene fusion. At the beginning, they were recognized in childhood; nevertheless, it has been demonstrated that these neoplasms can occur in adults as well. In the nineties, among Xp11 renal cell carcinoma, ASPL, PRCC, and SFPQ (PSF) were the first genes recognized as partners in TFE3 rearrangement. Recently, many other genes have been identified, and a wide spectrum of morphologies has been described. For this reason, the diagnosis may be challenging based on the histology, and the differential diagnosis includes the most common renal cell neoplasms and pure epithelioid PEComa/epithelioid angiomyolipoma of the kidney. During the last decades, many efforts have been made to identify immunohistochemical markers to reach the right diagnosis. To date, staining for PAX8, cathepsin K, and melanogenesis markers are the most useful identifiers. However, the diagnosis requires the demonstration of the ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research

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This study exposed various cellular and vascular components with distinct functions in the ovary of Redbelly tilapia during the spawning season.Graphical abstract
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: November 2019Source: Fish &Shellfish Immunology, Volume 94Author(s): Yaoguo Li, Shengzhen Jin, Xin Zhao, Hong Luo, Rui Li, Dongfang Li, Tiaoyi XiaoAbstractMDA5 is a cytoplasmic viral double-stranded RNA recognition receptor that plays a pivotal role in the aquatic animal innate immune system. To decipher the role of MDA5 of Squaliobarbus curriculus (ScMDA5) in the immune response, full-length cDNA of ScMDA5 was cloned using the RACE technology, mRNA and protein expression levels of ScMDA5 signalling pathway members in response to stimulation were detected and effects of overexpression of ScMDA5 on the...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: November 2019Source: Fish &Shellfish Immunology, Volume 94Author(s): Pei Li, Jianzhi Ye, Shaodong Zeng, Chunliang YangAbstractThe present study was conducted to evaluate the anti-inflammatory activity of florfenicol (FFC) against lipopolysaccharide (LPS)-induced inflammatory responses in Ctenopharyngodon idella in vivo and in vitro. Head-kidney (HK) macrophages were pre-treated with 10 μg/mL LPS and then exposed to different concentrations of FFC to determine its in vitro anti-inflammatory activity. Inhibitory effect of FFC on inflammatory mediators TNF-α, IL-6 and IL-1β, as well as LPS-...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
In this study, we used the Megalobrama amblycephala to investigate the effects of G. elegans alkaloids on fish intestinal health after diet supplementation with 0, 5, 10, 20 and 40 mg/kg G. elegans alkaloids for 12 weeks. We found that dietary G. elegans alkaloids at 40 mg/kg improved intestinal morphology by increasing villus length, muscle thickness and villus number in the foregut and midgut and muscle thickness in the hindgut (P 
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
In conclusion, the results provided further insight into the immune roles of galectin-1 in teleost.
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: November 2019Source: Fish &Shellfish Immunology, Volume 94Author(s): Cun Wei, Luqing Pan, Xin Zhang, Lijun Xu, Lingjun Si, Ruixue Tong, Hongdan WangAbstractAs a crucial neuroendocrine-immune factor, dopamine (DA) could regulate the immune system of Litopenaeus vannamei. To understand the immune mechanisms and regulatory pathways of DA in L. vannamei, the transcriptome analysis of hemocytes of L. vannamei with injection of DA (10−6 mol/shrimp) at 3 and 12 h were performed in this study. Moreover, quantitative real-time PCR (qPCR) method was applied to validate the accuracy of transcriptome se...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 21 September 2019Source: Process BiochemistryAuthor(s): Velusamy Arumugam, Manigandan Venkatesan, Selvakumar Murugesan, Rathinam Ayyasamy, Saravanan Ramachandran, Umamaheswari Sundaresan, Arivalagan PugazhendhiAbstractMarine ascidians contain potential bioactive compounds, which exhibit significant pharmacological activities. In the present study, the MeOH extract of Didemnum sp. was subjected to FT-IR, GC-MS analysis, the possible interactions with EGFR through docking analysis and in vitro cytotoxic activity against KB (Human oral cancer) cell line were also studied. The FT-IR analysis ...
Source: Process Biochemistry - Category: Biochemistry Source Type: research
[Vanguard] As part of ways to reduce the rising spate of cervical cancer cases in the country, Sebeccly Cancer Care organization launched the TimeToScreen 2019 programme on the 19th of September, 2019 at the Zenith House, Iga-Idunganran Primary Healthcare Centre, Iga-Idunganran, Lagos Island.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
ConclusionThose who use other cancer patients’ experiences to aid in their surgical decision-making enjoy a higher satisfaction with their decision.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
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Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
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