Longitudinal cognitive assessment in patients with primary CNS lymphoma treated with induction chemotherapy followed by reduced-dose whole-brain radiotherapy or autologous stem cell transplantation

ConclusionsResults indicated improvement in cognitive function up to 3  years post-treatment, but a decline at later time points and an increase in brain structure abnormalities in both groups. The findings suggest that rdWBRT and HDC-ASCT may be associated with delayed neurotoxicity in progression-free patients and underscore the need for long-term follow-up to chara cterize cognitive dysfunction in PCNSL patients.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research