Traditional Chinese Medicine for Coronary Heart Disease: Clinical Evidence and Possible Mechanisms

Abstract Coronary heart disease (CHD) remains a major cause of mortality with a huge economic burden on healthcare worldwide. Here, we conducted a systematic review to investigate the efficacy and safety of Chinese herbal medicine (CHM) for CHD based on high-quality randomized controlled trials (RCTs) and summarized its possible mechanisms according to animal-based researches. Twenty-seven eligible studies were identified in 8 database searches from inception to June 2018. The methodological quality was assessed using 7-item checklist recommended by Cochrane Collaboration. All the data were analyzed using Rev-Man 5.3 software. As a result, the score of study quality ranged from 4 to 7 points. Meta-analyses showed CHM can significantly reduce the incidence of myocardial infarction and percutaneous coronary intervention, and cardiovascular mortality (P
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research