Key Relevance of Epigenetic Programming of Adiponectin gene in Pathogenesis of Metabolic disorders.

Conclusion: Various studies have postulated that series of factors such as maternal High fat diet (HFD), oxidative stress, pro-inflammatory mediators, sleep fragmentation throughout lifetime, from gestation to old age, could accumulate epigenetic marks, including histone remodeling, DNA methylation, and microRNAs (miRNAs) that, in turn, alter the expression of ADIPOQ gene and results in hypoadiponectinemia which precipitates insulin resistance (IR) that in turn might induce or accelerate the onset and development of metabolic disorder. Better understanding of global patterns of epigenetic modifications and further their accordingly alterations in metabolic disorders will bestow the better treatment strategies design. PMID: 31368881 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research