Cell-Based Quadrivalent Inactivated Influenza Virus Vaccine (Flucelvax ® Tetra/Flucelvax Quadrivalent ® ): A Review in the Prevention of Influenza

AbstractManufacturing influenza virus vaccines using a mammalian cell line rather than embryonated chicken eggs may carry certain advantages. A quadrivalent inactivated influenza virus vaccine produced using the Madin Darby canine kidney cell line has been approved in the EU (Flucelvax® Tetra) and USA (Flucelvax Quadrivalent®; QIVc hereafter) for the prevention of influenza in adults and children. The clinical development of QIVc has built upon that of a cell-based trivalent influenza virus vaccine (TIVc) manufactured using the same processes; the additional influenza B strain contained in QIVc reduces the risk of the strain in the vaccine not matching that in circulation. Pivotal phase III clinical trials in adult and paediatric participants have demonstrated the immunogenicity of QIVc to be noninferior to that of TIVc formulations against shared strains and superior against the influenza B strain absent from each TIVc formulation. Protective efficacy data for TIVc is considered foundational for QIVc and, in a phase III clinical trial, TIVc was effective in protecting adults against antigenically matched influenza strains. Large real-world studies from the 2017/2018 US influenza season further support the prophylactic effectiveness of QIVc, with possible benefits over egg-based vaccines. QIVc was generally well tolerated in clinical trials. In adult and paediatric QIVc recipients, the most common solicited adverse reactions were injection site pain and headache. Reac...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research

Related Links:

For 10 acute pain conditions commonly managed in primary care settings, the probability of obtaining a refill after an initial 7-day opioid analgesic prescription ranged from 11% (headache) to 41% (musculoskeletal injury), with refill probability
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Acute-Care Hospitals Influenza (Flu) Influenza Vaccination MMWR Morbidity & Mortality Weekly Report Overdose Pain management Synthetic Opioids Source Type: news
​BY GREGORY TAYLOR, DO; DAWN ZELENKA-JOSHOWITZ, DO; &ANDREW TAECKER, DOA 34-year-old man presented with intermittent fever and body aches for 10 days. He had been visiting family in India, and the symptoms began when he returned home. His fever had been as high as 104°F, and he was experiencing nausea, two episodes of bilious emesis, body aches, nonspecific abdominal pain, and multiple episodes of watery, nonbloody diarrhea.He said he knew of no tuberculosis exposure or ill contacts, and he was current on his routine influenza and hepatitis A vaccines. His temperature was 101.4°F (he had taken acetaminophen t...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
AbstractVaccination is an essential tool in reducing the impact of seasonal influenza infections. The viral strains responsible for seasonal outbreaks vary annually, and preventive vaccines have to be adapted accordingly. The aim of this study was to evaluate the safety, clinical tolerability and the antibody response to each of the three influenza vaccine antigens after vaccination with a cell-derived, trivalent, surface antigen, inactivated influenza vaccine (TIVc), as measured by single radial haemolysis (SRH) or haemagglutination inhibition (HI) assay in accordance with European Union licensing guidelines in place for ...
Source: Infection - Category: Infectious Diseases Source Type: research
The 2017-2018 flu season was a bad one. The dominant viral strain, H3N2, was a particularly severe form of influenza, leading to widespread and serious illness across the country. The flu and its complications killed around 80,000 people last year, the CDC estimates, including 180 children. That’s the highest flu death toll in four decades. Experts say early indications suggest that this year’s flu season will be milder, but the memory of last winter should still serve as motivation to get the flu shot this fall. Here’s what you need to know about the 2018 flu shot. When should I get the flu shot? The CD...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime public health Source Type: news
Abstract Annual vaccination is the most effective way to prevent seasonal influenza illness. Instituto Butantan (IB) performed clinical studies with its 2013, 2014 and 2015 seasonal trivalent influenza vaccines (inactivated split-virion). Prospective cohort studies were carried out to describe the safety and immunogenicity of Instituto Butantan influenza vaccines, in healthy adults and elderly, from 2013 to 2015. Immediately after the informed consent was signed, participants underwent blood collection followed by vaccination. On study days 1, 2 and 3 post-vaccination participants were contacted by the staff to ev...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 009 The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with ...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 233. Readers can subscribe to FFFF RSS or subscribe to the FFFF weekly EMAIL Question 1: Who popularised museli? + Reveal the Funtabulous Answer expand(document.getElementById('ddet201504324'));expand(document.getElementById('ddetlink201504324')) Dr Maxi...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Frivolous Friday Five Bircher Bircher Museli Clare Stanton Ekbom syndrome II Ernest W Goodpasture Essex Lopresti Goodpastures disease hugo flecker irukandji irukandji syndrome jack barnes John Range Maximilian Bircher-Benner Pa Source Type: blogs
Seasonal influenza (or “flu”) is most often caused by type A or B influenza viruses. Symptoms include sudden onset of fever, cough (usually dry), headache, muscle and joint pain, sore throat and a runny nose. The cough can be severe and can last 2 or more weeks.
Source: WHO Feature Stories - Category: Global & Universal Tags: influenza [subject], flu, seasonal influenza, pandemic influenza, vaccines [subject], vaccine, vaccine safety, vaccine quality, Q & A [doctype] Source Type: news
Publication date: Available online 23 December 2016 Source:The Lancet Author(s): Ana Maria Henao-Restrepo, Anton Camacho, Ira M Longini, Conall H Watson, W John Edmunds, Matthias Egger, Miles W Carroll, Natalie E Dean, Ibrahima Diatta, Moussa Doumbia, Bertrand Draguez, Sophie Duraffour, Godwin Enwere, Rebecca Grais, Stephan Gunther, Pierre-Stéphane Gsell, Stefanie Hossmann, Sara Viksmoen Watle, Mandy Kader Kondé, Sakoba Kéïta, Souleymane Kone, Eewa Kuisma, Myron M Levine, Sema Mandal, Thomas Mauget, Gunnstein Norheim, Ximena Riveros, Aboubacar Soumah, Sven Trelle, Andrea S Vicari, John-Arne R&osl...
Source: The Lancet - Category: Journals (General) Source Type: research
  Zika continues to be the virus of the day for returning travelers, but there are several other diseases that we need to consider in these patients when they present to us in the emergency department. Chikungunya is epidemic in many of the same countries as Zika and can be even more devastating. And Avian and MERS-CoV is still present in many countries. Unlike patients infected with Zika virus, these patients do require isolation to protect our health care staff from infection. Chikungunya Chikungunya, which means “to walk bent over,” was likely endemic but unrecognized in the United States before the mos...
Source: EPMonthly.com - Category: Emergency Medicine Authors: Tags: Uncategorized Source Type: news
More News: Child Development | Children | Clinical Trials | Drugs & Pharmacology | Headache | Influenza | Influenza Vaccine | Migraine | Pain | Pediatrics | Study | Urology & Nephrology | Vaccines