The Protective Effect of Sonneratia apetala Fruit Extract on Acetaminophen-Induced Liver Injury in Mice.

The Protective Effect of Sonneratia apetala Fruit Extract on Acetaminophen-Induced Liver Injury in Mice. Evid Based Complement Alternat Med. 2019;2019:6919834 Authors: Liu J, Luo D, Wu Y, Gao C, Lin G, Chen J, Wu X, Zhang Q, Cai J, Su Z Abstract Acute liver injury is a common consequence of taking overdose of acetaminophen (APAP). The aim of this study was to evaluate the antioxidant activity and hepatoprotective effect of a mangrove plant Sonneratia apetala fruit extract (SAFE) on APAP-induced liver injury in mice. Mice were orally pretreated with SAFE (100, 200, and 400 mg/kg) daily for one week. The control and APAP groups were intragastrically administered with distilled water, and NAC group was treated with N-Acetyl-L-cysteine (NAC) before APAP exposure. The results manifested that SAFE significantly improved survival rates, attenuated hepatic histological damage, and decreased the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in serum in APAP-exposed mice. SAFE treatment also increased glutathione (GSH) level and glutathione peroxidase (GSH-Px) activity, enhanced catalase (CAT), and total antioxidant capacity (T-AOC), as well as reducing malondialdehyde (MDA) level in liver. In addition, the formation of tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), and elevation of myeloperoxidase (MPO) in APAP-exposed mice were inhibited after SAFE treatment. And SAFE also displayed high DPPH radical scavenging activ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Related Links:

Authors: Chinnappan SM, George A, Thaggikuppe P, Choudhary Y, Choudhary VK, Ramani Y, Dewangan R Abstract Paracetamol (PCM) is a well-known drug widely used for its analgesic and antipyretic properties. PCM is generally considered as safe but overdose of PCM can cause nephrotoxicity. Traditionally, herbs have been used for the treatment of drug or toxin-induced renal disorders and numerous medicinal plants were tested for nephroprotection effect in PCM-induced nephrotoxicity model. The aim of the present study was to evaluate the protective effect of the herbal extract Eurycoma longifolia (EL) against PCM-induced n...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Addiction is a chronic condition that leads to overdose and death. Addiction ruins lives, families and devastates communities. If you are suffering from addiction, it can be normal to ask yourself hard questions such as, “will I suffer from addiction forever? Is there a cure for addiction?” While there is no magic wand that can cure addiction, it is a treatable condition. When addiction is treated, people can go on to live normal, happy, healthy lives. While addiction may cause a lot of destruction and fractured relationships in its path, people can repair and move on from them as well. The Cure for Addiction:...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction Recovery Complementary Therapies Comprehensive behavioral treatment Healthy Eating and Recovery Mental Health Sober Living and Aftercare Substance Abuse addicted to alcohol addiction help addiction recovery programs Source Type: blogs
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
(Natural News) President Trump announced last year that the opioid epidemic was a “public health emergency” and called for the medical community to look for alternative therapies to battle the growing crisis. The President cited the most recent Centers for Disease Control and Prevention (CDC) statistics which places drug overdose as the leading cause of...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
There are few subjects that can stir up stronger emotions among doctors, scientists, researchers, policy makers, and the public than medical marijuana. Is it safe? Should it be legal? Decriminalized? Has its effectiveness been proven? What conditions is it useful for? Is it addictive? How do we keep it out of the hands of teenagers? Is it really the “wonder drug” that people claim it is? Is medical marijuana just a ploy to legalize marijuana in general? These are just a few of the excellent questions around this subject, questions that I am going to studiously avoid so we can focus on two specific areas: why do...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Complementary and alternative medicine Drugs and Supplements Health Pain Management Source Type: blogs
PITTSBURGH (AP) — The pain clinic tucked into the corner of a low-slung suburban strip mall was an open secret. Patients would travel hundreds of miles to see Dr. Andrzej Zielke, eager for what authorities described as a steady flow of prescriptions for the kinds of powerful painkillers that ushered the nation into its worst drug crisis in history. At least one of Zielke's patients died of an overdose, and prosecutors say others became so dependent on oxycodone and other opioids they would crowd his office, sometimes sleeping in the waiting room. Some peddled their pills near tumble-down storefronts and on blighted s...
Source: JEMS: Journal of Emergency Medical Services News - Category: Emergency Medicine Authors: Tags: News Administration and Leadership Source Type: news
BACKGROUND: A staggering number of Americans are dying from overdoses attributed to prescription opioid medications (POMs). In response, states are creating policies related to POM harm reduction strategies, overdose prevention, and alternative therapies f...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
A staggering number of Americans are dying from overdoses attributed to prescription opioid medications (POMs). In response, states are creating policies related to POM harm reduction strategies, overdose prevention, and alternative therapies for pain management, such as cannabis (medical marijuana). However, little is known about how the use of cannabis for pain management may be associated with POM use.
Source: Nursing Outlook - Category: Nursing Authors: Source Type: research
This reporting is brought to you by HuffPost’s health and science platform, The Scope. Like us on Facebook and Twitter and tell us your story: scopestories@huffingtonpost.com.   Sarah DiGiulio is The Huffington Post’s sleep reporter. You can contact her at sarah.digiulio@huffingtonpost.com.  -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Science - The Huffington Post - Category: Science Source Type: news
Medication-Assisted Treatment (MAT) is one of the most under-utilized tools we have to fight our country’s ongoing addiction crisis. Ideally, this intervention employs specific pharmaceutical drugs combined with counseling and behavioral therapies, but its true power is often obscured by misunderstanding. Effective use of MAT can make the difference between a long, healthy life and an untimely death by overdose. Here’s what you need to know about MAT and why people battling addiction should consider it. Decades of research shows that properly administered MAT is a safe, effective treatment option for substance...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Richard Taite Source Type: blogs
More News: Acetaminophen | Acetylcysteine | Alternative and Complementary Therapies | Antidoxidants | Carbohydrates | Complementary Medicine | Flavonoids | Fruit | Liver | Lortab | Overdose | Study | Urology & Nephrology