Interplay between the toxic alpha-gliadin peptide 31-43 and type 2 transglutaminase enzyme in Celiac Disease

Introduction: Celiac disease (CD) is a widespread enteropathy triggered by a diet containing cereals with gliadins in genetically predisposed individuals. Alpha-gliadin peptide 31 –43 (p31-43) is considered the main responsible of the innate immune response in CD patients and type 2 transglutaminase (TG2) enzyme is involved in CD by enhancing gliadin immunogenicity. Evidence has been reported on a role of TG2 in modulate p31-43 uptake by intestinal cells; indeed, antibodies to TG2 specifically reduced both p31-43 uptake by cells and its biological activity.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 20, 2019 Category: Nutrition Authors: Gaetana Paolella, Marilena Lepretti, Stefania Martucciello, Lill à Lionetti, Carla Esposito, Ivana Caputo Source Type: research