Acquisition of sensorimotor fMRI under general anaesthesia: Assessment of feasibility, the BOLD response and clinical utility

Publication date: Available online 2 July 2019Source: NeuroImage: ClinicalAuthor(s): Adam Kenji Yamamoto, Joerg Magerkurth, Laura Mancini, Mark J. White, Anna Miserocchi, Andrew W. McEvoy, Ian Appleby, Caroline Micallef, John S. Thornton, Cathy J. Price, Nikolaus Weiskopf, Tarek A. YousryAbstractWe evaluated whether task-related fMRI (functional magnetic resonance imaging) BOLD (blood oxygenation level dependent) activation can be obtained under conventional anaesthesia at a depth enabling neurosurgery in five patients with supratentorial gliomas. Within a 1.5 T MRI operating room immediately prior to neurosurgery, a passive finger flexion sensorimotor paradigm was performed on each hand with the patients awake, and then immediately after the induction and maintenance of combined sevoflurane and propofol general anaesthesia. The depth of surgical anaesthesia was measured and confirmed with an EEG-derived technique, the Bispectral Index (BIS). The magnitude of the task-related BOLD response and BOLD sensitivity under anaesthesia were determined. The fMRI data were assessed by three fMRI expert observers who rated each activation map for somatotopy and usefulness for radiological neurosurgical guidance.The mean magnitudes of the task-related BOLD response under a BIS measured depth of surgical general anaesthesia were 25% (tumour affected hemisphere) and 22% (tumour free hemisphere) of the respective awake values. BOLD sensitivity under anaesthesia ranged from 7%–83% compar...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research