First, do no harm? Common anticholinergic meds seen to increase dementia risk

Conclusions and Relevance: Exposure to several types of strong anticholinergic drugs is associated with an increased risk of dementia. These findings highlight the importance of reducing exposure to anticholinergic drugs in middle-aged and older people. The Study in Context: Study: 46.7 million Americans have Alzheimer’s Disease brain pathology today, so it’s urgent to prevent or at least delay progression to clinical disease From Anti-Alzheimer’s ‘Magic Bullets’ to True Brain Health Solving the Brain Fitness Puzzle Is the Key to Self-Empowered Aging Report: 35% of worldwide dementia cases could be prevented by modifying these 9 modifiable risk factors
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness anticholinergic anticholinergic drugs antipsychotics Benadryl dementi dementia risk diphenhydramine middle-aged older-people Parkinson's meds Source Type: blogs

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Authors: Ma F, Lv X, Du Y, Chen H, Liu S, Zhao J, Gao Y, An P, Zhou X, Song A, Sun C, Wang G, Ji Y, Wang X, Xu W, Huang G Abstract BACKGROUND: Leukocyte telomere length (LTL) is associated with the aging process and age-related degenerative diseases. The relation of peripheral blood LTL to mild cognitive impairment (MCI) and Alzheimer's disease (AD) and the role of folate and homocysteine (Hcy) in this relation remain unclear. OBJECTIVES: We aimed to investigate the association between LTL and the risks of MCI/AD, and to explore whether folate and Hcy may play a role in this association. METHODS: This case-...
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Authors: Li B, He Y, Ma J, Huang P, Du J, Cao L, Wang Y, Xiao Q, Tang H, Chen S Abstract OBJECTIVE: Gut microbiota changes before the onset of Alzheimer's disease (AD) and the alterations could be detected in the stage of mild cognitive impairment (MCI). The findings might offer diagnostic biomarkers before the onset of dementia. BACKGROUND: AD is the most common cause of dementia, and MCI is the predementia state. Recent studies suggest the alterations in the gut microbial communities associated with AD, whereas the microbiota in MCI before the onset of dementia has not been discovered and characterized in hum...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
OBJECTIVE: "13 Reasons Why," a Netflix series, included a controversial depiction of suicide that has raised fears about possible contagion. Studies of youth suicide in the United States found an increase on the order of 10% following release of the show, ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: Adolescence is characterized by an increased vulnerability for internalizing psychopathologies such as depression and anxiety. A positive association between anxiety and depression has consistently been found in research. However, the specific ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Source: International Journal of Tuberculosis and Lung Disease - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLES Source Type: research
Lung transplantation is an established therapeutic option for patients with irreversible end-stage pulmonary disease limiting life expectancy and quality of life. Common indications for lung transplantation include chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cystic fibrosis, pulmonary arterial hypertension, and alpha-1 antitrypsin deficiency. Complications of lung transplantation can be broadly divided etiologically into surgical, infectious, immunologic, or neoplastic. Moreover, specific complications often occur within a certain time interval following surgery, which can be broadly classified as...
Source: Journal of Thoracic Imaging - Category: Radiology Tags: Review Articles Source Type: research
Conclusions: The result of this study will help researchers to develop, plan and increase the qualitative and quantitative levels of their research on drowning. Similar to developed countries, developing research can help improve the culture and general education to prevent drowning in developing countries. 
Source: Journal of Injury and Violence Research - Category: International Medicine & Public Health Source Type: research
Source: American Journal of Health Behavior - Category: Psychiatry & Psychology Authors: Source Type: research
3rd year PT student here. Posting under a different alias since I do not want to use my pre-PT username. I'm not in the best place right now after just falling short of passing my first long-term clinical this past summer. I tried my best to appeal to the committee for my case for passing, but no avail. I feel really depressed that my graduation will be delayed by a whole year (granted everything goes right), and I'm just feeling my life has no purpose and life. I pushed aside my marathon... Failing A Clinical
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Physical Therapy Source Type: forums
Publication date: Available online 23 August 2019Source: Microbial PathogenesisAuthor(s): Lulu Chen, Jialong Zhang, Minmin Wang, Shuonan Pan, Chunxiao Mou, Zhenhai ChenAbstractSeneca Valley virus (SVV) has been identified as the causative agent of SVV-associated vesicular disease (SAVD). To investigate the pathogenicity of two newly isolated SVV strains (GD-S5/2018 and GD04/2017) in China, experimental infections of mice and pigs were performed. SVV GD-S5/2018 was lethal to mice infected by intramuscular, intraperitoneal, or oral routes, while SVV GD04/2017 was avirulent without causing any discernible clinical signs in mi...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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