FDA Approves Medication to Treat Female Sexual Disorder

The Food and Drug Administration (FDA) on Fridayapproved Vyleesi (bremelanotide) to treat premenopausal women for acquired, generalized hypoactive sexual desire disorder (HSDD). HSDD (classified as female sexual interest/arousal disorder inDSM-5) is characterized by low sexual desire that causes distress and cannot be explained by a comorbid physical or psychiatric illness, the side effects of substance use or medications, or severe relationship problems. Acquired HSDD means a woman has previously experienced sexual desire (it has not been a lifelong problem).“There are women who, for no known reason, have reduced sexual desire that causes marked distress and who can benefit from safe and effective pharmacologic treatment,” said Hylton V. Joffe, M.D., M.M.Sc., director of the FDA’s Division of Bone, Reproductive, and Urologic Products in the agency press release. “As part of the FDA’s commitment to protect and advance the health of women, we’ll continue to support the development of safe and effective treatments for female sexual dysfunction.”The approval of Vyleesi was supported by two 24-week, randomized clinical studies involving 1,247 premenopausal women with HSDD. In both trials, Vyleesi was more effective than placebo at improving patient-reported sexual desire and reducing emotional distress. Vyleesi is not approved to enhance sexual performance, and women should not use more than one dose every 24 hours or more than eight dose...
Source: Psychiatr News - Category: Psychiatry Tags: blood pressure female sexual interest/arousal disorder hypoactive sexual desire disorder naltrexone premenopausal women sexual dysfunction Vyleesi Source Type: research

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Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 20 July 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Carolina Villadóniga, Ana María B. CanteraAbstractAngiotensin converting enzyme (ACE) plays a key role in regulating blood pressure and ACE inhibitors are first-line drugs for treating hypertension. Food protein-derived peptides with ACE inhibitory activity are natural and safe alternatives for both prevention and treatment of hypertension. The second most abundant whey protein, α-lactalbumin (ALA) was hydrolysed with proteases from Bromelia antiacantha Bertol., a native plant. Two new peptides w...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
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Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
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Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Publication date: Available online 20 July 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): Dirk W. Lachenmeier, Stephan G. Walch, Jürgen Rehm
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research
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Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 21 July 2019Source: Respiratory Medicine Case ReportsAuthor(s): Meghan M. Cirulis, Lynda O. Jorgensen, Ronald W. DayAbstractThe pulmonary arterial pressure of a child with severe pulmonary arterial hypertension immediately normalized while breathing nitric oxide during heart catheterization at 8 years of age. Her acute pulmonary vascular response to nitric oxide has persisted throughout her life. Her acute response to other medications has been similar to her long-term response to medications in the same class. Acute vasodilator testing with inhaled nitric oxide and other medications may ...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
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Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: Use of RAS blockers (ACEI or ARB) in uncomplicated as well as complicated hypertensive patients with type 2 diabetes is sub-optimal. Most of the patients are on one drug and prescription of ≥3 drugs are rare. Statins are prescribed in only a half. PMID: 31321925 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
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Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
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