RIP3 promotes colitis-associated colorectal cancer by controlling tumor cell proliferation and CXCL1-induced immune suppression

Conclusion: Our results reveal an unexpected function of RIP3 in enhancing the proliferation of premalignant intestinal epithelial cells (IECs) and promoting myeloid cell-induced adaptive immune suppression. These two distinct mechanisms of RIP3-induced JNK and CXCL1 signalling contribute to CAC progression.

Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Zhen-Yu Liu, Ming Zheng, Yi-Ming Li, Xin-Yu Fan, Jian-Chao Wang, Zhu-Chun Li, Hai-Jiao Yang, Jing-Min Yu, Jian Cui, Jian-Li Jiang, Juan Tang, Zhi-Nan Chen Tags: Research Paper Source Type: research