The importance of early recognition of oral potentially malignant disorders in hiv-aids individuals.

Publication date: July 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 128, Issue 1Author(s): Prof. Itzel Castillejos GarcÍa, Dr. Velia Ramirez-Amador, Dr. Marcos MuÑiz Lino, Dr. Gabriela Anaya SaavedraObjectiveAn increase in head and neck cancer (HNC) in HIV-infected individuals has been described in several epidemiological studies, suggesting that immunosuppression, even in treated patients, may play a role in the development of HNC. A thorough oral examination is essential for the identification of potentially malignant lesions, particularly in individuals at high risk to develop cancer. Thus, we report two cases of oral potentially malignant disorders occurring in HIV individuals.Clinical PresentationCase 1. A 39-year-old male HIV+ since 2013. In 2015 presented an asymptomatic, slightly granular, red/white pediculate tumor on the left buccal mucosa, clinically compatible with multifocal epithelial hyperplasia with post-traumatic hyperkeratosis (251 cells/ml CD4+, undetectable viral load [VL]). Two weeks later, the lesion showed marked erosive/ulcerated areas, thus, a complete excision was done. The final diagnosis was in situ squamous cell carcinoma positive to HPV-16. Case 2. A 40-year-old male HIV+ since 2005, with histologically confirmed oral hairy leukoplakia, immunohistochemistry showed positive expression to EBV and negative to HPV. In 2015 presented a white well circumscribed homogeneous plaque, with a slightly roug...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research

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Source: Pathology Research and Practice - Category: Pathology Source Type: research
We present for the first time a case of MFS of the breast induced by radiotherapy.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Conclusions: Results suggest TCC may have a small positive effect on early outcomes, but use of the services was highly variable among sites. Level of Evidence: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Publication date: Available online 20 October 2019Source: The LancetAuthor(s): Daniel I Sessler, Lijian Pei, Yuguang Huang, Edith Fleischmann, Peter Marhofer, Andrea Kurz, Douglas B Mayers, Tanja A Meyer-Treschan, Martin Grady, Ern Yu Tan, Sabry Ayad, Edward J Mascha, Donal J Buggy, Gang Tan, Zhiyong Zhang, Helen Keane, Maurice Stokes, Oliver Zotti, Michael Gnant, Silvia Perez-ProttoSummaryBackgroundThree perioperative factors impair host defence against recurrence during cancer surgery: the surgical stress response, use of volatile anaesthetic, and opioids for analgesia. All factors are ameliorated by regional anaesthesia...
Source: The Lancet - Category: General Medicine Source Type: research
CCR Grand Rounds Dr. Jabado ’ s research focuses on elucidating genetic signatures of pediatric astrocytomas and examining how they compare to adults. These are deadly brain tumors that originate in the brain and include glioblastomas (GBM, the highest grade of astrocytomas), which are one of the deadliest cancers in humans. Her group uncovered that pediatric high-grade astrocytomas (HGA) are molecularly and genetically distinct from adult tumors. They also identified a new molecular mechanism driving pediatric HGA, namely recurrent somatic driver mutations in the tail of histone 3 variants (H3.3 and H3.1). These mut...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Publication date: December 2019Source: Biomedicine &Pharmacotherapy, Volume 120Author(s): Tiantian Cai, Chengzhe Zhang, Xiaohui Zeng, Ziming Zhao, Yan Yan, Xuhua Yu, Lei Wu, Lin Lin, Huafeng PanAbstractGastric cancer is recognized as one of the most common cancer. In-depth research of gastric precancerous lesions (GPL) plays an important role in preventing the occurrence of gastric cancer. Meanwhile, traditional treatment provides a novel sight in the prevention of occurrence and development of gastric cancer. The current study was designed to assess the effects of therapy with Weipixiao (WPX) decoction on N-methyl-N'-...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Basosquamous carcinomas (BSCs), which comprise 1.2 –2.7% of skin carcinomas, are aggressive skin tumors that feature histopathologic characteristics of both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). BSC origin and genetic etiology remain controversial. Chiang and colleagues reported underlying PTCH and SMO mutations in BSCs, su ggesting that Hedgehog signaling drives BSC similar to BCC. Principal component analysis indicated that BSC has greater genetic similarity to BCC than to SCC, supporting the concept that BSCs are derived from BCCs.
Source: Journal of Investigative Dermatology - Category: Dermatology Tags: Clinical Snippets Source Type: research
Basosquamous carcinoma (BSC) is a rare form of skin cancer with both basaloid and squamous morphology. Chiang et  al. (2019) genetically define BSCs and demonstrate that BSCs likely originate as basal cell carcinomas that partially squamatize through accumulation of ARID1A mutations and RAS/MAPK pathway activation.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Commentary Source Type: research
BOWEL cancer is a general term for cancer that begins in a person ’s large bowel. Symptoms typically involve changes in a person’s stools. Here are three warning signs to watch out for.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
More News: Cancer | Cancer & Oncology | Carcinoma | ENT & OMF | Epidemiology | Epithelial Cancer | Head and Neck Cancer | HIV AIDS | Oral Cancer | Pathology | Post Traumatic Stress Disorder | Radiology | Skin Cancer | Squamous Cell Carcinoma | Study