Metformin Induces Apoptosis and Inhibits Proliferation through the AMP-Activated Protein Kinase and Insulin-like Growth Factor 1 Receptor Pathways in the Bile Duct Cancer Cells

Conclusions: Metformin has antineoplastic effects in bile duct cancer, and hyperglycemic environment interrupts the effect of metformin. In addition, AMPK and IGF-1R play a key role in the proliferation of bile duct cancer cells.

Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jin Lee, Eun Mi Hong, Jung Han Kim, Jang Han Jung, Se Woo Park, Dong Hee Koh, Min Ho Choi, Hyun Joo Jang, Sea Hyub Kae Tags: Research Paper Source Type: research