Hawaii ranked No. 1 in the state for highest life expectancy

According to a new study by SeniorLiving.org on Life Expectancy In Every U.S. State, Hawaii is the No. 1 state in America, with the highest life expectancy of 81.3 years old in 2018.  California is next on the list at 80.9 and Mississippi is the lowest at 74.7. U.S. life expectancy declined nationally for the third consecutive year in 2018 due to increases not only in cancer and heart disease, as the two biggest causes of death in America, but also suicide, drug overdoses and liver disease connected…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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Publication date: 15 February 2020Source: Journal of Molecular Structure, Volume 1202Author(s): Yu Yang, Jiang-Yu Bian, Yu-Han Li, Hui-Chao Guan, Yan-Ru Tang, Yan-Ling Chen, Shu-Mei YueAbstractSix complexes including [Cd (bpt)(odc)2] (1), [Ni(bpt)(odc)2] (2), [Zn (bpt)(odc)2] (3), [Zn (bpt)(1,4-ndc)2(H2O)] (4), [Cd (bpt)(1,4-ndc)2] (5), [Cd (bpt)(Pta)2(H2O)2] (6), {bpt = 2-(2 pyridyl)benzothiazole, H2odc = 4,4′-oxybisbenzoic acid, 1,4-H2ndc = naphthalene-1,4-dicarboxylic acid, Pta = terephthalic acid}, have been determined by single-crystal X-ray diffraction analysis, which shows that complexes 1&ndas...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 19 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Brittany Haynes, Ambikai Gajan, Pratima Nangia-Makker, Malathy P. ShekharAbstractTriple negative breast cancer (TNBC) is an aggressive breast cancer subtype with few therapy options besides chemotherapy. Although platinum-based drugs have shown initial activity in BRCA1-mutated TNBCs, chemoresistance remains a challenge. Here we show that RAD6B (UBE2B), a principal mediator of translesion synthesis (TLS), is overexpressed in BRCA1 wild-type and mutant TNBCs, and RAD6B overexpression correlate...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Publication date: Available online 19 October 2019Source: Life SciencesAuthor(s): Mostafa M. Salah, Ahmed A. Ashour, Tamer M. Abdelghany, Abdel-Aziz H. Abdel-Aziz, Salama A. SalamaAbstractAimsLiver fibrosis (LF) is a life-threatening complication of most chronic liver diseases resulting from a variety of injurious agents and hepatotoxic insults. To date, there are no specific therapies for LF, and all the currently available drugs have been developed for other indications. Thus, there is a pressing need to develop new drugs for treatment of LF. Therefore, the current study aimed to elucidate the potential antifibrotic effe...
Source: Life Sciences - Category: Biology Source Type: research
In this study, we compared differences in gene expression in parental and CHD4-deficient cells by next-generation sequencing and Ingenuity Pathway Analysis.Key findingsWe found that β1 integrin is a downstream target gene of CHD4, which could be transcriptionally regulated by CHD4 in TNBC cells. Consistent with in vitro data, immunohistochemistry revealed that co-expression of β1 integrin and CHD4 was significantly associated with metastatic state, recurrence, and survival status in TNBC patients. It also showed a positive correlation between β1 integrin and CHD4 in vivo.SignificanceThis is the first study t...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 19 October 2019Source: Carbohydrate PolymersAuthor(s): Katarzyna Ratajczak, Magdalena StobieckaAbstractA remarkable progress in the development of portable paper-based biosensors (PBBs) and microfluidic paper-based analytical devices (µPADs) has recently been achieved. In these devices, a paper formed of microfibers of cellulose, a carbohydrate biopolymer, offers both an ample space in its micropores for analytical reagents storage and a capillary force to drive liquid samples to a dedicated reaction zone for instantaneous detection of the desired analytes. Owing to the low cost and...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 19 October 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Javad Mohammadian, Hossein Miladi-GorjiAbstractGender- and age-dependent effects on the severity of morphine dependence are still controversial. The aim of this study was to investigate the effects of age and sex on the severity of physical and psychological dependence in morphine-dependent rats. The young/aged male and female Wistar rats were chronically treated with bi-daily doses (10 mg/kg, at 12 h intervals) of morphine for 14 days. Then, rats were tested for the severity of physical dependence on morphine (...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Publication date: 1 December 2019Source: Journal of Non-Crystalline Solids, Volume 525Author(s): Qianqian Wang, Mingxiu Chen, Liliang Shao, Youwen Ge, Pinghua Lin, Chenglin Chu, Baolong ShenAbstractThe effects of structural relaxation on the catalytic efficiency of FePC amorphous ribbons in the Fenton-like reactions are studied. Different from previous knowledge, the catalytic efficiency of the Fe-based amorphous ribbons doesn't decrease linearly with increased annealing temperature before glass transition. The catalytic ability of the FePC ribbons annealed at 553 and 593 K is worse than that of as-quenched ribbons, whil...
Source: Journal of Non Crystalline Solids - Category: Chemistry Source Type: research
Young Americans are dying in rising numbers because of drugs, alcohol and suicide, according to new federal data. The Centers for Disease Control and Prevention’s National Center for Health Statistics (NCHS) issued its annual comprehensive health and mortality report, which analyzes trends in death rates by cause and demographic. Drugs, alcohol and suicide, the report says, have contributed to the first drops in U.S. life expectancy since 1993. While U.S. life expectancy rose from 77.8 to 78.6 years between 2006 and 2016, the trend reversed during the end of the decade, leading to a 0.3-year decline between 2014 and ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Research Source Type: news
Young Americans are dying in rising numbers because of drugs, alcohol and suicide, according to new federal data. The Centers for Disease Control and Prevention’s National Center for Health Statistics (NCHS) issued its annual comprehensive health and mortality report, which analyzes trends in death rates by cause and demographic. Drugs, alcohol and suicide, the report says, have contributed to the first drops in U.S. life expectancy since 1993. While U.S. life expectancy rose from 77.8 to 78.6 years between 2006 and 2016, the trend reversed during the end of the decade, leading to a 0.3-year decline between 2014 and ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Research Source Type: news
I almost wound up accidentally missing the tree for the forest by immediately posting on Ma et al's "Temporal Trends in Mortality in the United States, 1969-2013," in last week's JAMA. (You should be able to read the abstract here.) Fantastic news, it seems. During that slightly more than 4 decades, the age-adjusted death rate in the U.S. fell by 43%. Death rates were down for all major causes except for COPD, a remaining echo of the tobacco epidemic. The biggest killers, cancer and heart disease, showed big declines, although the decline for cancer has leveled off.But, as it turns out, buried in all the good new...
Source: Stayin' Alive - Category: American Health Source Type: blogs
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