Curcuminoid WZ26, a TrxR1 inhibitor, effectively inhibits colon cancer cell growth and enhances cisplatin-induced cell death through the induction of ROS.

This study discloses a previously unrecognized mechanism underlying the biological activity of WZ26, and reveals that WZ26 and cisplatin combinational treatment might potentially become a more effective regimen in colon cancer therapy. PMID: 31176737 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31176737?dopt=Abstract

Source: Free Radical Biology and Medicine - June 5, 2019 Category: Biology Authors: Zhang T, Zheng P, Shen X, Shao R, Wang B, Shen H, Zhang J, Xia Y, Zou P Tags: Free Radic Biol Med Source Type: research