Arginine Starvation and Docetaxel Induce c-Myc-Driven hENT1 Surface Expression to Overcome Gemcitabine Resistance in ASS1-Negative Tumors.

CONCLUSIONS: The priming of tumors with ADI-PEG20 and docetaxel results in the stabilization of c-MYC potentiating the effect of GEM treatment via an increase in hENT1 expression. This finding is applicable to ASS1-deficient cancers that are currently treated with GEM.
PMID: 31113844 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - May 20, 2019 Category: Cancer & Oncology Authors: Prudner BC, Rathore R, Robinson AM, Godec AJ, Chang SF, Hawkins WG, Hirbe AC, Van Tine BA Tags: Clin Cancer Res Source Type: research