Cancers, Vol. 11, Pages 694: New Insights into Molecular Oncogenesis and Therapy of Uveal Melanoma

Cancers, Vol. 11, Pages 694: New Insights into Molecular Oncogenesis and Therapy of Uveal Melanoma Cancers doi: 10.3390/cancers11050694 Authors: Sara Silvia Violanti Ilaria Bononi Carla Enrica Gallenga Fernanda Martini Mauro Tognon Paolo Perri Uveal melanoma (UM), which is the most common cancer of the eye, was investigated in recent years by many teams in the field of biomedical sciences and eye clinicians. New knowledge was acquired on molecular pathways found to be dysregulated during the multistep process of oncogenesis, whereas novel therapeutic approaches gave significant results in the clinical applications. Uveal melanoma-affected patients greatly benefited from recent advances of the research in this eye cancer. Tumour biology, genetics, epigenetics and immunology contributed significantly in elucidating the role of different genes and related pathways during uveal melanoma onset/progression and UM treatments. Indeed, these investigations allowed identification of new target genes and to develop new therapeutic strategies/compounds to cure this aggressive melanoma of the eye. Unfortunately, the advances reported in the treatment of cutaneous melanoma have not produced analogous benefits in metastatic uveal melanoma. Nowadays, no systemic adjuvant therapy has been shown to improve overall survival or reduce the risk of metastasis. However, the increasing knowledge of this disease, and the encouraging results seen in clinical trials, offer promise for...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research