Convergent neurobiological predictors of mood and anxiety symptoms and treatment response.

Convergent neurobiological predictors of mood and anxiety symptoms and treatment response. Expert Rev Neurother. 2019 May 16;: Authors: Jabbi M, Nemeroff CB Abstract INTRODUCTION: Mood and anxiety disorders are a leading contributor to the global burden of diseases. Comorbid mood and anxiety disorders have a lifetime prevalence of over 20% globally and increases the risk for suicide, one of the leading causes of death in Europe and North America. Areas covered: In this narrative review, the authors highlight recent advances in the understanding of multi-level neurobiological mechanisms for normal and pathological human affective functioning. The authors then address the complex interplay between environmental adversity and molecular-genetic mediators of these neurobiological correlates of affective symptoms. The molecular focus is strategically limited to three genes GTF2i, BDNF, and FKBP5 that are respectively involved in transcriptional, neurodevelopmental and neuroendocrine pathway mediation of affective functions. The importance of these genes is illustrated with studies of a) copy number variants, b) genome-wide association studies (GWAS), and c) candidate gene sequence variant associations with affective disorder etiology. The authors conclude this review by highlighting the predictive values of integrative neurobiological processes that influenced by gene-environment interactions and mediate affective disorder symptoms and their management. Expert...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research