IJERPH, Vol. 16, Pages 1726: Finasteride-Induced Inhibition of 5 α-Reductase Type 2 Could Lead to Kidney Damage—Animal, Experimental Study

IJERPH, Vol. 16, Pages 1726: Finasteride-Induced Inhibition of 5α-Reductase Type 2 Could Lead to Kidney Damage—Animal, Experimental Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16101726 Authors: Mirza Saim Baig Agnieszka Kolasa-Wołosiuk Anna Pilutin Krzysztof Safranow Irena Baranowska-Bosiacka Joanna Kabat-Koperska Barbara Wiszniewska In the pharmacological treatment of prostate cancer, benign prostatic hyperplasia and androgenetic alopecia finasteride is commonly used. This drug inhibits 5α-reductase type 2, which is why finasteride affects androgen homeostasis, since testosterone (T) cannot be reduced to dihydrotestosterone (DHT). As studies on sex-related renal injuries suggest a high probability of androgen-induced renal dysfunction, the aim of this study was to determine the potential harmful effects of finasteride on the kidneys of rats. The study was performed on sexually mature male Wistar rats given finasteride. Histological sections of the kidneys were used for immunohistochemical visualization of the androgen receptor (AR), junctional proteins (occluding (Occ); E-cad, N-cad, E-/N-cadherin; β-cat, β-catenin; connexin 43 (Cx43)), proliferating cell nuclear antigen (PCNA), IL-6, and lymphocyte markers (CD3 for T cell, CD19 for B cell). The TUNEL method was used for cell apoptosis identification, and picro sirius red staining was used to assess collagen fibers thi...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research

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