Metformin INHIBITS β-Catenin PHOSPHORYLATION ON SER-552 through an AMPK/PI3K/AKT Pathway in colorectal cancer cells.
Metformin INHIBITS β-Catenin PHOSPHORYLATION ON SER-552 through an AMPK/PI3K/AKT Pathway in colorectal cancer cells.
Int J Biochem Cell Biol. 2019 May 10;:
Authors: Amable G, Martínez-León E, Picco ME, Di Siervi N, Davio C, Rozengurt E, Rey O
Abstract
Several epidemiologic studies have revealed strong inverse associations between metformin use and risk of colorectal cancer development. Nevertheless, the underlying mechanisms are still uncertain. The Wnt/β-catenin pathway, which plays a central role in intestinal homeostasis and sporadic colorectal cancer development, is regulated by phosphorylation cascades that are dependent and independent of Wnt. Here we report that a non-canonical Ser552 phosphorylation in β-catenin, which promotes its nuclear accumulation and transcriptional activity, is blocked by metformin via AMPK-mediated PI3K/Akt signaling inhibition.
PMID: 31082618 [PubMed - as supplied by publisher]
Source: The International Journal of Biochemistry and Cell Biology - Category: Biochemistry Authors: Amable G, Martínez-León E, Picco ME, Di Siervi N, Davio C, Rozengurt E, Rey O Tags: Int J Biochem Cell Biol Source Type: research
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