O48. Retinal Function Anomalies in Young Offspring at Genetic Risk of Major Affective and Non-Affective Disorders: Significance for the Illness Pathophysiology

Visual defects are well documented in psychiatric disorders such as schizophrenia, bipolar disorder and major depressive disorder. One of the most replicated alteration in patients is decreased electroretinographic (ERG) responses. We previously showed a diminished rod b-wave amplitude in a small sample of children born to an affected parent (H ébert 2010). The fact that an ERG anomaly found in patients would also be observed in children at high genetic risk (HR) suggests a neurodevelopmental origin.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research