T171. Implication of FOXP2 and DRD2 in the Associations Between Computerized Device Use and Psychiatric Disorders

Computerized device uses (CDU; e.g., playing computer games (CompGaming), mobile phone use (minutes/week for the last three months (PhoneUse) and total usage years), hands-free/speakerphone device use). Epidemiological associations between CDUs and psychiatric disorders are frequently reported; the biological mechanisms underlying these observations remain unknown. We investigated genetic overlap and causality between CDUs and psychiatric disorders (attention deficit hyperactivity disorder (ADHD), schizophrenia (SCZ), autism spectrum disorder, major depressive disorder, alcohol dependence, bipolar disorder, anorexia nervosa, and posttraumatic stress disorder) using LD score regression (LDSC) and Mendelian randomization (MR).
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research

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Low paid work (not strictly volunteer work) to an underserved community (e.g. scribe for ADHD students, ESL instructor). This isn't clinical work. It's also not nonclinical volunteering (because there's a low hourly rate being paid). So how do ad coms regard this? Medical scribing: This seems like shadowing except as a much more rewarding learning experience. On another thread, several posters suggested that scribing be treated as clinical experience and that additional... Which box gets checked?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Medical - MD Source Type: forums
Publication date: Available online 22 June 2019Source: Social Science &MedicineAuthor(s): Andrew Gibbs, Rachel Jewkes, Samantha Willan, Mahfuz Al Mamun, Kausar Parvin, Marat Yu, Ruchira NavedAbstractWorkplace violence (WPV) is widely reported in the Bangladeshi garment industry, impacting women workers' health and wellbeing. We explore factors associated with female workers experience or witnessing of WPV and perpetration by managers, in eight Bangladeshi garment factories. We hypothesise workers' experience of WPV is associated with i) individual factors, potentially impacting productivity (age, depression, length of ...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 23 June 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Muneeb A. Faiq, Gadi Wollstein, Joel S. Schuman, Kevin C. ChanAbstractThe cholinergic system has a crucial role to play in visual function. Although cholinergic drugs have been a focus of attention as glaucoma medications for reducing eye pressure, little is known about the potential modality for neuronal survival and/or enhancement in visual impairments. Citicoline, a naturally occurring compound and FDA approved dietary supplement, is a nootropic agent that is recently demonstrated to be effective in ameliorating ischemi...
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research
Conclusions No statistically significant association between bothersome urinary symptoms and the odds of screening positive for increased risk of postpartum depression was found. Future work in this area is needed.
Source: Female Pelvic Medicine and Reconstructive Surgery - Category: OBGYN Tags: Original Articles Source Type: research
Publication date: Available online 24 June 2019Source: Brain, Behavior, and ImmunityAuthor(s): Qiang Liu, Lingli Yan, Miaodan Huang, Haitao Zeng, Senthil Kumaran Satyanarayanan, Zhe Shi, Dingbang Chen, Jia-Hong Lu, Zhong Pei, Xiaoli Yao, Huanxing SuAbstractAlcoholism is a risk factor for the development of cognitive decline and dementia. Here we demonstrated that the glymphatic function in the brain was impaired by alcohol administration. Acute moderate alcohol administration substantially retarded and reduced the entry of subarachnoid cerebrospinal fluid (CSF) via the paravascular space into the cerebral parenchyma, thus ...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Despite admitting to the extent of her eating problem, then 16-year-old Meg Smith's GP told her she wasn't ill enough to warrant help. She now studies special effects and media make-up in Leeds.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
A library of 14 nontoxic diterpenoid-like compounds (CC50> 70 µM on HepG2 human liver cells) was screened against Mycobacterium smegmatis, Staphylococcus aureus and Escherichia coli to determine antimicrobial activity. Some compounds with a phenethyl alcohol core substituted with a β-cyclocitral derivative demonstrated anti-mycobacterial activity, with the most active being compound 1 (MIC = 23.4 mg/L, IC50 = 0.6 mg/L). Lower activity was exhibited against S. aureus, while no activity was displayed against E. coli. Low cytotoxicity was confirmed on HepG2 cells and newly derived for RAW 264.7 murine macrophage...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Non-alcoholic steatohepatitis (NASH) is the leading cause of chronic liver injury and the third most common reason for liver transplantations in Western countries. It is unclear so far how different fat sources in Western diets (WD) influence the development of non-alcoholic steatohepatitis. Our study investigates the impact of non trans fat (NTF) and corn oil (Corn) as fat source in a WD mouse model of steatohepatitis on disease development and progression. C57/B6J wildtype (WT) mice were fed “standard” WD (WD-Std), WD-NTF or WD-Corn for 24 weeks. WT animals treated with WD-NTF exhibit distinct features of the...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
AbstractThe study aimed at validating the Hindi and English versions of PERMA and WEMWBS on Indian adolescent population. The data were collected from 1288 adolescents, aged 13 –18 years (mean age = 15.27 years, SD = 1.08). Both the scales were an adequate fit to the data, indicating high reliability. For PERMA (α = 0.90), a set of 34 items had the best fit out of the original item pool of 49 items. For the WEMWBS (α = 0.84), original one factor model with 14 items was confirmed in the Indian adolescent population as well. Multivariate anal...
Source: Child Indicators Research - Category: Child Development Source Type: research
In Canada, about 23 per cent of mothers who recently gave birth reported feelings consistent with either postpartum depression or an anxiety disorder.
Source: CBC | Health - Category: Consumer Health News Tags: News/Health Source Type: news
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