First case-report: designer Quaalude intoxication

methylmethaqualone methaqualone           3.5 out of 5 stars Acute neurotoxicity associated with recreational use of methylmethaqualone confirmed b liquid chromatography tandem mass spectrometry. Ceschi A et al. Clin Toxicol 2013;52:54-7. Abstract Methylmethaqualone (MMQ) is a designer drug made by adding a methyl group to the long-restricted sedative-hypnotic molecule methaqualone (Quaalude). This paper represents the first case report describing a confirmed case of methylmethaqualone toxicity. A 24-year-old man presented to the emergency department approximately 2-3 hours after washing down several MMQ tablets with wine. Shortly after this, he was found at home somnolent but suddenly became extremely agitated with urinary incontinence and generalized clonic muscle contractions. When paramedics arrived the patient was agitated and confused, but improved with 10 mg IV midazolam. In the ED, he was confused but not agitated. Vital signs were unremarkable except for a heart rate of 115/min. He had a mild resting tremor but no nystagmus. EKG was normal. Urine drug screen was negative. A serum sample — analyzed by liquid chromatography tandem mass spectrometry — was positive for MMQ but no other medications or drugs of abuse. The patient was observed overnight and discharged the next day. Ten days later the patient again came to the ED with a similar presentation after ingesting MMQ. He responded to midazolam, and was discharged after 2 hours of obs...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical Keith Richards mandrax methaqualone methylmethaqualone quaalude Source Type: news