Celastrol Protects RPE Cells from Oxidative Stress-Induced Cell Death via Activation of Nrf2 Signaling Pathway.

CONCLUSION: This study provides evidence that treatment of RPE cells with celastrol shows potent protective effects against oxidative insults via activation of Nrf2 signaling pathway and upregulation of GCLM expression. This finding suggests that celastrol might be used as a potential therapeutic agent for oxidative stress-related eyes diseases, such as AMD.
PMID: 31032752 [PubMed - as supplied by publisher]

Source: Current Molecular Medicine - April 23, 2019 Category: Molecular Biology Authors: Zhou Y, Zhou L, Zhou K, Zhang J, Shang F, Zhang X Tags: Curr Mol Med Source Type: research