Utility of Skin Biopsy and Culture in the Diagnosis and Classification of Chronic Ulcers: A Single-Institution, Retrospective Study

Abstract: In the United States, chronic ulcers affect 6.5 million people, with a cost of ≈$20 million annually. The most common etiology of chronic ulcers in the United States is venous stasis, followed by arterial insufficiency and neuropathic ulcers. Less common causes of chronic ulcers include infection, inflammatory etiologies such as vasculitis and pyoderma gangrenosum, and neoplastic causes. Obtaining skin biopsy and tissue culture can be helpful in diagnosing unusual causes of chronic ulcers; however, there are little data on the diagnostic utility of skin biopsy in rendering a definitive diagnosis of the etiology of chronic ulcers. A retrospective study of all skin ulcers biopsied during a 10-year period at the University of Washington was undertaken. Re-excisions and surgical wounds were excluded. A total of 270 ulcer biopsy specimens were included. In 48% of cases, no specific diagnosis could be rendered histologically. 44.8% of chronic ulcers biopsied were due to atypical causes, with neoplasms (basal cell carcinoma, squamous cell carcinoma, melanoma, and cutaneous T-cell lymphoma) being the most common. Vasculitis and pyoderma gangrenosum each represented 1.5% of rendered diagnoses. Concomitant skin culture was performed in 28.9% of cases, and special stains [acid-fast bacilli, Brown and Brenn (B&B), Grocott's methenamine silver, and periodic acid-Schiff stains] were performed in 34.0%. Although more than half (49 of 78) of tissue cultures were positive, o...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Original Study Source Type: research

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We report the case of a 17-year-old patient with recurrent hemorrhagic pericardial effusion, who was diagnosed with primary pericardial fibrosarcoma. However, multiple radiological examinations, including CT and [18F] FDG/PET-CT, suggested the presence of fluid and no sign of tumor. Actually, when a patient presents with recurrent hemorrhagic pericardial effusions, pericardial tumors must be taken into account as part of the differential diagnosis.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
CONCLUSIONS IQGAP3 may be a potential target gene for Kaempferol in the treatment of BC, and upregulation of IQGAP3 inhibits Kaempferol-induced apoptosis in BC cells by ERK1/2 signaling activation. Targeting IQGAP3 may contribute to the study of natural phytochemicals as anti-tumor drugs in BC. PMID: 31605603 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
John SamplesElizabeth Warren ’s presidential campaign has a new Facebook ad claiming Mark Zuckerberg, the CEO of Facebook, has endorsed Donald Trump for re-election. That claim is false, and Warren admits as much in the ad. Warren is not trying to mislead people about Zuckerberg. She is trying to control what can be said on Facebook. That is much more dangerous than any lie appearing in a campaign ad.Recently the Trump campaign ran an ad on Facebook saying former vice president Joe Biden had sought to fire a Ukrainian prosecutor investigating a company whose board included Biden ’s son. Many on the left like Wa...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
Publication date: Available online 12 October 2019Source: Journal of Neuroscience MethodsAuthor(s): Cristina Miliano, E. Reilly Scott, Laura B. Murdaugh, Emma R. Gnatowski, Christine L. Faunce, Megan S. Anderson, Malissa M. Reyes, Ann M. Gregus, Matthew W. BuczynskiAbstractSmoking tobacco products is the leading cause of preventable death worldwide. Coordinated efforts have successfully reduced tobacco cigarette smoking in the United States; however, electronic cigarettes (e-cigarette) and other electronic nicotine delivery systems (ENDS) recently have replaced traditional cigarettes for many users. While the clinical risk...
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Publication date: Available online 12 October 2019Source: Physiology &BehaviorAuthor(s): Genevieve R. Curtis, Jensine M. Coudriet, Lilia Sanzalone, Nancy Mack, Lauren M. Stein, Matthew R. Hayes, Jessica R. BarsonAbstractBinge eating disorder (BED), the most common eating disorder in the United States, is characterized by binge-type eating and is associated with higher body mass index and greater motivation for food. This disorder tends to first appear in late adolescence or young adulthood and is more common in women than men. While some animal models of BED have recapitulated both the overeating and the excessive body...
Source: Physiology and Behavior - Category: Physiology Source Type: research
Conclusion: MTV and TLG calculations using MFS are reproducible, generate similar results to those obtained with MV and are much less timing consuming. Main differences between the two methods were related to difficulties in avoiding overlay of VOIs in the MV technique. MV and MFS perform equally well in in patients with small number of lesions. PMID: 31604902 [PubMed - as supplied by publisher]
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
Authors: Kay MD, Morris-Wiseman LF, Beazer A, Winegar BA, Kuo PH Abstract A 56-year old male received a total thyroidectomy, bilateral central and right lateral neck dissection for papillary thyroid carcinoma with lymph nodes metastases. Prior to radioiodine ablation the pre-therapy 123I scan established the diagnosis of primary nasolacrimal duct obstruction (dacryostenosis). PMID: 31604890 [PubMed - as supplied by publisher]
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
Publication date: Available online 13 October 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Zoran M. Marković, Svetlana P. Jovanović, Pavle Z. Mašković, Marija M. Mojsin, Milena J. Stevanović, Martin Danko, Matej Mičušík, Dragana J. Jovanović, Angela Kleinová, Zdeno Špitalský, Vladimir B. Pavlović, Biljana M. Todorović MarkovićAbstractPhotoactive materials called photosensitizers can be used for treatment of different types of cancer in combination with light source. In this paper, we have investigated pro-oxidant and antioxidant potentials of...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
CONCLUSION: Accurate assessment of the regional lymph node status by SNB is becoming even more important in the era of novel effective adjuvant therapies for microscopic nodal disease. Whether complete lymph node dissection is performed in patients with a positive SN needs to be assessed individually. In the case of "active nodal surveillance" instead of surgery, long-term close follow-up in specialized centers, including ultrasonographic controls, is required. PMID: 31605168 [PubMed - as supplied by publisher]
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
Publication date: Available online 12 October 2019Source: The Journal of the Economics of AgeingAuthor(s): Corina Mommaerts, Syed Hassan Raza, Yu ZhengAbstractThis paper estimates the effect of hospital admissions among older workers on economic outcomes across countries. We use harmonized longitudinal survey data from the United States, China, and 13 countries in Europe, and follow the event study design of Dobkin et al., 2018 to estimate dynamic effects of a hospitalization on out-of-pocket health expenditures, labor market outcomes, social insurance payments, and household income. We find distinctly different patterns a...
Source: The Journal of the Economics of Ageing - Category: Health Management Source Type: research
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