Effects of GRM4, SCN2A and SCN3B Polymorphisms on Antiepileptic Drugs Responsiveness and Epilepsy Susceptibility

ConclusionThis study identified no significant associations of allelic or genotypic SNPs with the susceptibility of epilepsy and medication response with an exception of rs2304016 and rs2499697 SNPs that were associated with the generalized type of epilepsy among Jordanian population. Further studies are required in different populations to confirm our results and identify genetic factors that involved in susceptibility and treatment response.
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research