Exposure to prenatal antidepressant alters medial prefrontal-striatal synchronization in mice.

Exposure to prenatal antidepressant alters medial prefrontal-striatal synchronization in mice. Brain Res. 2019 Apr 12;: Authors: Jiang J, Zheng Y, Chen Y, Zahra A, Long C, Yang L Abstract Citalopram (CTM), a selective serotonin reuptake inhibitor (SSRI), has been widely used to treat panic disorders, such as depression which is one of the most disabling, yet common, psychiatric disorders. Although prenatal antidepressant exposure has a major impact on the neurobehavioral development of the offspring, such as anxiety, depression- and autism-like behaviors, the brain alterations of SSRI influence remained largely unknown. We show here, using electrophysiological recordings, that CTM exposure during the last 7 d of gestation can alter theta- and gamma-band oscillation and synchronization in the corticostriatal loop of 2-3 month-old mouse offspring. The dendritic length and number of dendritic branches in prefrontal neurons of these CTM-exposed mice are significantly reduced, consistent with decreased levels of N-methyl-D-aspartate receptors (NMDARs) and calcium/calmodulin-dependent protein kinase II (CaMKII) in the medial prefrontal cortex (mPFC). In addition, the level of c-Fos in both the mPFC and striatum is significantly increased. Together, these results advance our understanding of a neural network that is potentially responsible for abnormalities induced by prenatal antidepressant exposure. PMID: 30986408 [PubMed - as supplied by publisher]
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research

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Authors: Carmassi C, Bertelloni CA, Salarpi G, Diadema E, Avella MT, Dell'Oste V, Dell'Osso L Abstract This case report highlights the relevance of the consequences of trauma in a female patient with an undetected autism spectrum disorder (ASD) affected by bipolar disorder (BD) with multiple comorbidities. A 35-year-old woman with BD type II, binge eating disorder and panic disorder was admitted in the Inpatient Unit of the Psychiatric Clinic of the University of Pisa because of a recrudescence of depressive symptomatology, associated with increase of anxiety, noticeable ruminations, significant alteration in neuro...
Source: Case Reports in Psychiatry - Category: Psychiatry Tags: Case Rep Psychiatry Source Type: research
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Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Adolescent health Anxiety and Depression Behavioral Health Mental Health Parenting Source Type: blogs
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Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Alternative and Nutritional Supplements Anxiety and Panic Brain and Behavior Exercise & Fitness General Habits Happiness Health-related Mental Health and Wellness Mindfulness Personal Compassion Integrative Medicine Mind Body Wel Source Type: blogs
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Source: Pharmacopsychiatry - Category: Psychiatry Authors: Tags: Original Paper Source Type: research
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Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: confidence creativity featured self improvement best inspirational quotes best self-improvement blogs creative genius how to be bold how to build confidence pickthebrain self confidence Source Type: blogs
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Source: PLOS Currents Muscular Dystrophy - Category: Neurology Authors: Source Type: research
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