Prevalence of BRCA1 and BRCA2 gene mutations in Chinese patients with high-risk breast cancer.

CONCLUSION: We found that patients with triple-negative breast cancer had a higher frequency of BRCA1 mutations than those with non-triple-negative breast cancer. In this study, no significant associations between the BRCA1/2 mutation status and age, family history of breast cancer, ovarian cancer, pancreatic cancer and prostate cancer, number of primary lesions, tumor size, or lymph node metastasis were observed. PMID: 30968603 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30968603?dopt=Abstract

Source: Molecular Medicine - April 8, 2019 Category: Molecular Biology Authors: Wang X, Liu H, Maimaitiaili A, Zhao G, Li S, Lv Z, Wu D, Shi A, Guan X, Jia H, Li M, Song D, Kang L, Han B, Fu T, Yang M, Zhu Z, Du Y, Song Y, Hong J, Fan Z Tags: Mol Genet Genomic Med Source Type: research