Alstrom syndrome: insulin resistance in young with congestive heart failure

We report a case of a 20-year-old presenting with decompensated heart failure and had been blind since childhood who was eventually diagnosed as Alstrom syndrome based on clinical criteria.
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research

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Source: BMJ Comments - Category: General Medicine Source Type: forums
Two Clinical Nurse Specialist opportunities are available to contribute towards the provision of excellent patient care within our Endocrinology and Diabetes Service.One post will be for our Queen Elizabeth Hospital (QEHB) site and the other for our Heartlands, Good Hope and Solihull Hospital site (HGS). Successful candidates will join a team of experienced specialist nurses in a tertiary Endocrine referral centre and will be given full structured training and supervision to develop their skills in Endocrinology.Application deadline is2 February 2020. Visit www.jobs.nhs.uk for full details and to apply. 
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Researchers reports an over 50% drop in overall death rates among people with diabetes living in Hong Kong from 2001-2016; younger people with diabetes less likely to experience improvement in survival, however.Medscape Medical News
Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news
Conclusion It was safety to discontinued oral antiplatelet agents before operation, with no MACE and death in perioperative period. 
 DOI: 10.3779/j.issn.1009-3419.2020.01.06
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
CONCLUSIONS Our results highlight that interaction of Nr4a1 and LKB1 can mitigate T2DM by activating the AMPK/SIRT1 signaling pathway and inhibiting NF-kappaB activation. This may offer new insight for T2DM treatment. PMID: 31939452 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 15 January 2020Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Antonio Armario, Javier Labad, Roser NadalAbstractARMARIO, A, J. Labad and R. Nadal. Focusing attention on biological markers of acute stressor intensity: empirical evidence and limitations. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. The availability of biological markers that objectively quantify stress is a highly relevant issue. However, experimental evidence suggests that most physiological changes elicited by emotional stressors do not reflect their intensity and are not useful for this purpose. Thus, we review exp...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Authors: Fontes MAP, Marzano LAS, Silva CC, Silva ACSE Abstract Despite the current availability of safe and efficient drugs for treating hypertension, a substantial number of patients are drug-resistant hypertensives. Aiming this condition, a relatively new approach named catheter-based renal denervation was developed. We have now a clinically relevant time window to review the efficacy of renal denervation for treating this form of hypertension. This short review addresses the physiological contribution of renal sympathetic nerves for blood pressure control and discusses the pros and cons of renal denervation pro...
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
Authors: Du Z, Xu W, Chen X, Xu D, Li Y, Zhang H, Gao L PMID: 31937077 [PubMed - as supplied by publisher]
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Authors: Saritas T, Floege J Abstract Patients with chronic kidney disease (CKD) are at increased risk for kidney failure, cardiovascular disease (CVD), and death. In fact, the likelihood of dying from CVD is markedly higher than that for reaching end-stage renal disease. Evidence-based management of comorbidities such as CVD remains challenging in patients with advanced CKD, as they were usually excluded from randomized controlled trials. This review focuses on the epidemiology, risk factors, and clinical manifestations of CVD in patients with advanced CKD. Specific topics of interest include diagnostic and therap...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
Publication date: Available online 16 January 2020Source: Life SciencesAuthor(s): Milad Ashrafizadeh, Zahra Ahmadi, Saeed Samarghandian, Reza Mohammadinejad, Habib Yaribeygi, Thozhukat Sathyapalan, Amirhossein SahebkarAbstractMicroRNAs (miRs) are small non-coding pieces of RNA that are involved in a variety of physiologic processes such as apoptosis, cell proliferation, cell differentiation, cell cycle and cell survival. These multifunctional nucleotides are also capable of preventing oxidative damages by modulating antioxidant defense systems in a variety of milieu, such as in diabetes. Although the exact molecular mechan...
Source: Life Sciences - Category: Biology Source Type: research
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