Nanomedical detection and downstream analysis of circulating tumor cells in head and neck patients.

Nanomedical detection and downstream analysis of circulating tumor cells in head and neck patients. Biol Chem. 2019 Mar 01;: Authors: Künzel J, Gribko A, Lu Q, Stauber RH, Wünsch D Abstract The establishment of novel biomarkers in liquid biopsies of cancer patients comes more into focus of prognostic and diagnostic research efforts. Due to their prognostic relevance disseminated tumor cells or circulating tumor cells are the subject of intensive research, and are discussed as early diagnostic indicators for treatment failure and the formation of micrometastases. A potential association of this early-systemic tumor component with poor prognosis of cancer patients could be already demonstrated for various entities including breast, colon, lung, melanoma, ovarian, and prostate cancers. Thus, the detection of circulating tumor cells seems to be also applicable for minimal-invasive monitoring of therapy progress in head and neck cancer patients. A major problem of the use in clinical routine is that circulating tumor cells could not be detected by modern imaging techniques. To overcome these limitations highly sensitive detections methods and techniques for their molecular characterization are urgently needed allowing mechanistic understanding and targeting of circulating tumor cells. Especially the medical application of nanotechnology (nanomedical methods) has made valuable contributions to the field. Here, we want to provide a comprehensive overvi...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research

Related Links:

Authors: Conte SC, Spagnol G, Biolo M, Confalonieri M Abstract The conventional-trans bronchial needle aspiration (c-TBNA) has been the first procedure for sampling hilar/mediastinal lymph node for the diagnosis/staging of lung cancer. In the last decade the endobronchial ultrasound trans bronchial needle aspiration (EBUS-TBNA) was introduced in clinical practice and became the first-choice exam in diagnosis and staging of lung cancer. The aim of this study was to compare the diagnostic accuracy (DA), sensitivity and adequacy of c-TBNA and EBUS-TBNA. It was a retrospective and observational multicenter study. The f...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Publication date: 18 April 2019Source: Cell, Volume 177, Issue 3Author(s): Wantong Yao, Anirban MaitraIn this issue of Cell, Lytle et al. (2019) integrate functional genomic approaches to identify molecular dependencies of pancreatic cancer stem cells that may be exploited therapeutically. The comprehensive analysis reveals an unexpected role for retinoic acid receptor-related orphan receptor gamma (RORγ), a T-cell-associated transcription factor, in defining the stemness and the aggressive behavior of pancreatic cancer.
Source: Cell - Category: Cytology Source Type: research
In conclusion, our results indicated that CEP55 played an important role in promoting the invasion and migration of U251 cell and self-renewal of glioma stem like cells which might be a new therapeutic target for glioma.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: Available online 18 April 2019Source: NeurocomputingAuthor(s): Pengyi Hao, Kun You, Haozhe Feng, Xinnan Xu, Fan Zhang, Fuli Wu, Peng Zhang, Wei ChenAbstractEarly detection of lung cancer is the most promising path to increase the chance of survival for patients. Accurate lung nodule detection in computed tomography (CT) images is a crucial step in diagnosing lung cancer. CNN based CADe systems diagnose lung nodules in two stages by using one network for detection and another following network for classification or false positive reduction. Besides costly construction, two-stage systems can only find a sin...
Source: Neurocomputing - Category: Neuroscience Source Type: research
Authors: Simsek FS, Arslan M, Dag Y Abstract In some non-small cell lung cancer (NSCLC) patients, lipid-poor adrenal adenomas cannot be adequately differentiated from metastases using imaging methods. Invasive diagnostic procedures also have a low negative predictive value (NPV) in such cases. The current study aims to establish a specific and clinically practical metabolic parameter for lipid-poor adrenal lesions (ALs) in NSCLC patients. This diagnostic approach may prevent unnecessary abdominal enhanced computed tomography (CT), magnetic resonance imaging, or invasive diagnostic procedures. Sixty-four NSCLC patie...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Authors: Niu JC, Ma N, Liu W, Wang PJ Abstract Recent studies showed that the activation of prostaglandin (PG) receptor EP1 promotes cell migration and invasion in different cancers. The aim of this study was to investigate the role of EP1 in the proliferation of osteosarcoma (OS) cells in vitro and in vivo. EP1 mRNA and protein levels were analyzed by real-time RT-PCR and Western blot, respectively in human OS cell lines MG63, OS732, U-2OS, HOS and SAOS-2 compared to human fetal osteoblastic hFOB 1.19 cells. MG63 cells were treated with PGE2, EP1 specific agonist 17-PT-PGE2, 17-PT-PGE2 + EP1 specific antagonist SC...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Conclusion: Based on the results of our present study, ruxolitinib may potentially lead to the pathological expression of the transcription factors important in lymphoma genesis, neoplastic commitment on the progenitor lymphoid cells, inhibition of repressor transcriptions protective for lymphoma development, inhibition of apoptosis, promotion of neoplastic proliferation, transcriptional activation, and proliferation of malignant neoplastic B cells. PMID: 30997981 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Authors: Hopancı Bıçaklı D, Çehreli R, Özveren A, Meseri R, Uslu R, Karabulut B, Akçiçek F Abstract Background/aim: The purpose of this study was to determine sarcopenia, sarcopenic obesity and phase angle (PA) and the influence of chemotherapy (CT) on anthropometric measurements and and the PA in in geriatric patients with gastrointestinal (GI) cancer. Materials and methods: The anthropometric measurements, calf circumference (CC), upper midarm circumference (UMAC), and hand grip strength (HGS), have been measured to understand muscle function of 153 patients (mean age of 70...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
This study provides mechanistic insights into the potential role(s) of autophagy in BPV disease, which can help to develop future treatment and control measures for BPV infection. Activation of autophagy correlates positively with BPV infection and may play a role in biological behavior of bladder cancer as urothelial carcinomas of cattle are known to be characterized by a relatively low rate of metastasis.
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
This study demonstrated that using the dual-energy method could improve classification performance because the microcalcifications are affected by the density and thickness of the breast phantom. These results indicate that the classification accuracy was improved when the difference between the low-energy image and high-energy image was used. The dual-energy method can reduce the frequency of the need for biopsies and discriminate between different types of microcalcifications in mammography. These results can improve the efficiency of early breast cancer diagnosis.
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
More News: Cancer | Cancer & Oncology | Chemistry | Colon Cancer | Colorectal Cancer | Head and Neck Cancer | HNSCC | Melanoma | Molecular Biology | Nanotechnology | Ovarian Cancer | Ovaries | Prostate Cancer | Skin Cancer