Nanomedical detection and downstream analysis of circulating tumor cells in head and neck patients.

Nanomedical detection and downstream analysis of circulating tumor cells in head and neck patients. Biol Chem. 2019 Mar 01;: Authors: Künzel J, Gribko A, Lu Q, Stauber RH, Wünsch D Abstract The establishment of novel biomarkers in liquid biopsies of cancer patients comes more into focus of prognostic and diagnostic research efforts. Due to their prognostic relevance disseminated tumor cells or circulating tumor cells are the subject of intensive research, and are discussed as early diagnostic indicators for treatment failure and the formation of micrometastases. A potential association of this early-systemic tumor component with poor prognosis of cancer patients could be already demonstrated for various entities including breast, colon, lung, melanoma, ovarian, and prostate cancers. Thus, the detection of circulating tumor cells seems to be also applicable for minimal-invasive monitoring of therapy progress in head and neck cancer patients. A major problem of the use in clinical routine is that circulating tumor cells could not be detected by modern imaging techniques. To overcome these limitations highly sensitive detections methods and techniques for their molecular characterization are urgently needed allowing mechanistic understanding and targeting of circulating tumor cells. Especially the medical application of nanotechnology (nanomedical methods) has made valuable contributions to the field. Here, we want to provide a compre...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research