Molecular basis of high glucose-mediated cardiac calcium mishandling
ConclusionOur data suggests that HG alters Ca2 + signalling via Epac2–mediated pro-arrhythmic events due a CaMKII-dependent increase of RyR2 activity. Overtime, this newly described mechanism lowers systolic Ca2 + release as seen in diabetic-associated cardiomyopathy.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
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