Appropriate Management of Attenuated Familial Adenomatous Polyposis: Report of a Case and Review of the Literature

We present a case of a 22-year-old female with AFAP who was treated with endoscopic polypectomy and surveilled by annual colonoscopy. Guidelines for AFAP surveillance suggest annual colonoscopy with endoscopic polypectomy in asymptomatic individuals. Indications for immediate surgery include documented or suspected cancer or significant symptoms. Preferred surgical option in AFAP is colectomy and ileo-rectal anastomosis. Surveillance of the AFAP patients should include upper GI endoscopy and duodenoscopy with random biopsies of fundic gland polyps and endoscopic resection of detected adenomas. Annual thyroid ultrasound is indicated due to increased risk for thyroid cancer. In pediatric patients tested positive for germline mutation ofAPC gene screening for hepatoblastoma using alpha-fetoprotein and liver ultrasound should be performed.Dig Dis
Source: Digestive Diseases - Category: Gastroenterology Source Type: research