Statins, myalgia, and rhabdomyolysis

Publication date: Available online 6 February 2019Source: Joint Bone SpineAuthor(s): Anne TournadreAbstractStatin-associated muscle symptoms (SAMSs) vary considerably in frequency and severity, with a spectrum extending from myalgia with normal creatine kinase (CK) levels or asymptomatic hyperCKemia to potentially life-threatening rhabdomyolysis and necrotizing autoimmune myopathy. Myalgia with CK elevation is the most common presentation. Onset is usually within 1 month after statin initiation or dosage intensification, and the symptoms can be expected to resolve within a few weeks after treatment discontinuation. The mechanism of muscle injury combines statin accumulation within muscles, which varies with the type and dosage of the drug; muscle fragility; abnormalities in statin transport or liver metabolism; drug-drug interactions; and genetic susceptibility. HMG-CoA reductase inhibition in muscles by statins exerts pleiotropic effects that can affect energy metabolism, induce mitochondrial dysfunction, modify lipid oxidation, promote apoptosis and cell membrane lysis, alter muscle protein synthesis, or trigger an autoimmune process. Statins are used to treat several chronic conditions and comorbidities, including inflammatory rheumatic diseases, which are associated with an increased cardiovascular risk. When the cardiovascular risk is high or very high, statin therapy is indispensable and has a very favorable risk/benefit ratio. Otherwise, the risks should be weighed aga...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research

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Publication date: Available online 23 October 2019Source: Life SciencesAuthor(s): Qi Li, Xinglan An, Xiaxia Man, Meiran Chu, Tianchuang Zhao, Hao Yu, Ziyi LiAbstractAimsThe present study aimed to investigate the effects of cyclophosphamide (Cytoxan, CTX) on premature ovarian failure (POF) in mice and its regulatory mechanisms by transcriptome analysis.Main methodsFemale C57BL/6 mice were treated with a single intraperitoneal injection of 70 mg/kg CTX. Serum levels of estradiol (E2) and follicle stimulating hormone (FSH) were measured by enzyme-linked immunosorbent assay (ELISA), and follicular structure differences were ob...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 22 October 2019Source: Life SciencesAuthor(s): Chao He, Guiting Zhang, Hang Ouyang, Peng Zhang, Yudan Chen, Ren Wang, Hong ZhouAbstractAimsβ2-glycoprotein I/anti-β2-glycoprotein I antibody complex (β2/aβ2) could promote oxLDL-induced endothelial inflammation through Toll-like receptor 4 (TLR4), therefore accelerates atherosclerosis in patients with anti-phospholipid syndrome (APS). However, effects of β2/aβ2 and TLR4 on oxLDL-induced CD36 activation in macrophages remain to be elucidated and are currently under investigation.Materials and MethodsTHP-1 macroph...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 22 October 2019Source: MitochondrionAuthor(s): Linchi Rani, Amal Chandra MondalAbstractMitochondria are very dynamic organelle which play a multifactorial role for a broad range of physiological processes inside the cell to maintain neural circuit integrity. They are required for the generation of cellular energy, regulation of calcium homeostasis and controlling programmed cell death. Defective mitochondrial homeostasis is frequently reported in a broad range of neurological disorders. Many lines of evidence suggest that it plays an essential role in aging, and neurodegeneration. Parkins...
Source: Mitochondrion - Category: Biochemistry Source Type: research
Publication date: Available online 22 October 2019Source: MitochondrionAuthor(s): Sonia A. Allen, Sandipan Datta, Jose Sandoval, Alexey Tomilov, Thomas Sears, Kevin Woolard, James M. Angelastro, Gino A. CortopassiAbstractAMP-activated protein kinase (AMPK) is a eukaryotic energy sensor and protector from mitochondrial/energetic stress that is also a therapeutic target for cancer and metabolic disease. Metformin is an AMPK inducer that has been used in cancer therapeutic trials. Through screening we isolated cetylpyridinium chloride (CPC), a drug known to dose-dependently inhibit mitochondrial complex 1, as a potent and dos...
Source: Mitochondrion - Category: Biochemistry Source Type: research
A Triangle contact research organization has netted a massive federal contract, positioning the company to receive a steady stream of revenue for several years. Durham-based Duke Clinical Research Institute will receive $90 million in funding from the National Institute of Aging and the National Heart, Lung,&Blood – both subsets of the National Institutes of Health (NIH). The award will fund the first study into the effectiveness of statins –  a class of lipid-lowering medications prescribed…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Publication date: Available online 22 October 2019Source: Preventive MedicineAuthor(s): Mette Stavnsbo, Eivind Aadland, Sigmund A. Anderssen, Mai Chinapaw, Jostein Steene-Johannessen, Lars B. Andersen, Geir K. ResalandAbstractThe onset of cardiometabolic diseases are recognized to occur in childhood. We aimed to investigate the effect of a school-based cluster-randomized controlled trial of physical activity (PA) on single and clustered cardiometabolic risk factors.We included 1129 fifth-grade children from 57 schools (≥seven children in each class) in Sogn and Fjordane County, Norway. The PA intervention was conducted ...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
We report a case of sarcoidosis complicated by cirrhosis and portal hypertension with finger clubbing. Clinicians should bear in mind that cirrhosis, portal hypertension and clubbing may arise as the initial manifestations of sarcoidosis. PMID: 31631644 [PubMed - in process]
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Acquired pure red cell aplasia and acquired amegakaryocytic thrombocytopenic purpura are rare in children. Similarly, clonal expansion of T-cell large granular lymphocytes is infrequently seen in pediatrics. Lipopolysaccharide-responsive beige-like anchor (LRBA) protein deficiency is a recently described immunodeficiency syndrome that has been associated with inflammatory bowel disease and autoimmune phenomena such as Evans syndrome. Here, we describe a patient with LRBA deficiency who developed acquired pure red cell aplasia and acquired amegakaryocytic thrombocytopenic purpura associated with expansion of clonal T-cell l...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research
ConclusionBased on our results we can assume that atorvastatin and rutin had positive effect on spatial memory and vessel reactivity. Atorvastatin optimized lipid profile of blood serum.
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
The agency proposed that surgeons discuss the risks with patients and that manufacturers print bold warnings on the device packaging.
Source: NYT Health - Category: Consumer Health News Authors: Tags: your-feed-science Implants Breasts Medical Devices Breast Cancer Plastic Surgery Labeling and Labels (Product) Surgery and Surgeons Silicone Autoimmune Diseases Allergan Inc Food and Drug Administration Source Type: news
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