Modulating native GABA A receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death

ConclusionGABRA5 expression can serve as a diagnostic biomarker for group 3 tumors, while α5-GABAAR is a therapeutic target for benzodiazepine binding, enhancing an ion imbalance that induces apoptosis.

Source: Journal of Neuro-Oncology - February 6, 2019 Category: Cancer & Oncology Source Type: research