Premenopausal cardiovascular disease and age at natural menopause: a pooled analysis of over 170,000 women

We examined whether premenopausal CVD events are associated with early age at menopause. We pooled the individual data of 177,131 women from nine studies. We used multinomial logistic regression models to estimate multivariable relative risk ratios (RRR) and 95% confidence intervals (CI) for the associations between age at onset of premenopausal CVD events —including coronary heart disease (CHD) and stroke—and age at natural menopause. Altogether 1561 (0.9%) premenopausal participants reported CVD events (including 1130 CHD and 469 stroke) at a mean age of 41.3 years. Compared with women without any premenopausal CVD events, women who experienced a first CVD event before age 35 years had a twofold risk of menopause before age 45 years (early menopause); adjusted RRR (95% CI) of 1.92 (1.17, 3.14) for any CVD, 1.86 (1.01, 3.43) for CHD and 2.17 (1.43, 3.30) for stroke. Women who experienced a first premenopausal CVD event after age 40 year s underwent a natural menopause at the expected age (around 51 years). These associations were robust to adjustment for smoking status, BMI, educational level, race/ethnicity, age at menarche, parity, hypertension and family history of CVD. For premenopausal women, a first CVD event before age 35  years is associated with a doubling of the risk of an early menopause, while a first CVD event occurred after 35 years indicates a normal menopause at around 51 years. Shared genetic and environmen...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research

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Publication date: March 2019Source: The Annals of Thoracic Surgery, Volume 107, Issue 3Author(s): Raymond A. Jean, Alexander S. Chiu, Jessica R. Hoag, Justin D. Blasberg, Daniel J. Boffa, Frank C. Detterbeck, Anthony W. KimBackgroundReadmissions after pulmonary lobectomy for lung cancer are important markers of healthcare quality for surgeons and hospitals. The implications on resources and quality are magnified when examining patients who require multiple readmissions within the perioperative period.MethodsThe Nationwide Readmission Database between 2013 and 2014 was investigated for patients with a primary diagnosis of l...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ConclusionsThe current study identified risk factors for major adverse outcome after proximal thoracic aortic surgery with hypothermic circulatory arrest for degenerative pathology. The proposed simple, accurate model can quantify risk and facilitate physician-patient counseling before possible surgical intervention.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
SMARTChip biosensor undergoing clinical trials in England could pave way for clinical laboratories to provide additional diagnostic tests for monitoring patient progress Emergency medical workers and mobile clinical laboratory technicians may soon have a point-of-care blood test that can identify patients having a stroke from its earliest moments. Currently being developed by Sarissa Biomedical at […]
Source: Dark Daily - Category: Laboratory Medicine Authors: Tags: Instruments & Equipment Laboratory Instruments & Laboratory Equipment Laboratory Management and Operations Laboratory News Laboratory Operations Laboratory Pathology Laboratory Testing Management & Operations Source Type: news
CONCLUSIONS: Patients were evaluated more efficiently in the RACPC than in a traditional cardiology clinic, and their subsequent rates of emergency department re-attendances and adverse cardiovascular events were lower. PMID: 30773636 [PubMed - as supplied by publisher]
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
This study reviews the circumstances and medical causes of death of motor vehicle drivers who died in circumstances of sudden illness whilst behind the wheel in Victoria, Australia 2012-13. The driver’s fitness to drive assessment history was also examined to identify prevention opportunities.Deaths included in the study were those referred to a panel responsible for determining whether the driver fatality should be included in the official road toll, where prior doubt exists. A research team comprising of forensic physicians examined the case file of each death involving sudden illness.Forty-five driver deaths durin...
Source: Journal of Forensic and Legal Medicine - Category: Forensic Medicine Source Type: research
In this study, we examined the benefits of early-onset, lifelong AET on predictors of health, inflammation, and cancer incidence in a naturally aging mouse model. Lifelong, voluntary wheel-running (O-AET; 26-month-old) prevented age-related declines in aerobic fitness and motor coordination vs. age-matched, sedentary controls (O-SED). AET also provided partial protection against sarcopenia, dynapenia, testicular atrophy, and overall organ pathology, hence augmenting the 'physiologic reserve' of lifelong runners. Systemic inflammation, as evidenced by a chronic elevation in 17 of 18 pro- and anti-inflammatory cytokin...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Menopausal symptoms can be annoying, but did you ever think they could be life-threatening??A Mayo Clinic study found some common menopausal symptoms may be linked to obstructive sleep apnea?? a condition that can lead to serious health issues, including increased risks of?coronary heart disease,?high blood pressure?and?stroke. Watch: The Mayo Clinic Minute Journalists: Broadcast-quality video [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
Conclusion This large pooled cohort study seems to demonstrate an association between a healthy plant-based diet and reduced risk of coronary heart disease, and an increased risk of heart disease with an unhealthy plant-based diet. This adds to the evidence base supporting the possible benefits of healthy plant-based diets in protecting against certain illnesses. However there are some limitations to the research: The cohort included only health professionals from the US so might not be representative of wider populations in the UK or elsewhere. The study can't provide information on the benefits or otherwise of this d...
Source: NHS News Feed - Category: Consumer Health News Tags: Food/diet Source Type: news
Conclusion This study has found that while overall gluten consumption in people without coeliac disease may not be related to heart disease risk, avoiding whole grains (wheat, barley and rye) in order to avoid gluten may be associated with increased heart disease risk. This study has several strengths, including its large size, the fact that data was collected prospectively and diet assessed at several time-points, the long period of follow up, and that it took into account a wide range of potential confounders. As with all studies of this type, it is possible that other factors may affect the results. However, the researc...
Source: NHS News Feed - Category: Consumer Health News Tags: Food/diet Heart/lungs Source Type: news
CONCLUSION: In a middle-aged subset population, SUA is associated with better performance on an executive function test in men, but not in women in the ELSA-Brasil cohort study. PMID: 28300627 [PubMed - as supplied by publisher]
Source: Experimental Gerontology - Category: Geriatrics Authors: Tags: Exp Gerontol Source Type: research
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