Imbalanced spinal infiltration of Th17/Treg cells contributes to bone cancer pain via promoting microglial activation.

In conclusion, T cells infiltrated into the spinal cord with the imbalance of Th17/Treg towards Th17 during the development of BCP, which could promote the microglial activation and further increased BCP, while neutralizing IL-17/IL-17A in the spinal cord could ameliorate BCP. Our results suggest that targeting the imbalanced Th17/Treg infiltration in the spinal cord could be a novel strategy for BCP therapy.
PMID: 30685532 [PubMed - as supplied by publisher]

Source: Brain, Behavior, and Immunity - January 24, 2019 Category: Neurology Authors: Huo W, Liu Y, Lei Y, Zhang Y, Huang Y, Mao Y, Wang C, Sun Y, Zhang W, Ma Z, Gu X Tags: Brain Behav Immun Source Type: research