Artificial activation of cancer cells to destroy them

(Far Eastern Federal University) This risky method of anti-cancer therapy was suggested by scientists of Far Eastern Federal University (FEFU). Their review of mechanisms for molecular activation of stem cells of gliomas (most widely-spread brain tumors) was approved for publishing in the Frontiers in Cellular Neuroscience journal.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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ConclusionPDT remains a promising therapeutic approach that requires further study in HGGs. Use of 5-ALA PDT permits selective tumor targeting due to the intracellular metabolism of 5-ALA. The immunomodulatory effects of PDT further strengthen its use for treatment of HGGs and requires a better understanding. The combination of PDT with adjuvant therapies for HGGs will need to be studied in randomized, controlled studies.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
Publication date: 14 January 2019Source: Cancer Cell, Volume 35, Issue 1Author(s): Patrick Sin-Chan, Iqra Mumal, Annie HuangDiffuse intrinsic brain stem gliomas (DIPGs) with characteristic K27M mutation of H3.3 are lethal and poorly understood childhood cancers. In this issue of Cancer Cell, Larson et al. exploit a unique murine DIPG model with inducible, endogenous K27M expression to reveal insights into mechanisms of K27M-mediated transformation in DIPG.
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Publication date: Available online 11 January 2019Source: Acta Pharmaceutica Sinica BAuthor(s): Caifang Gao, Jianming Liang, Ying Zhu, Chengli Ling, Zhekang Cheng, Ruixiang Li, Jing Qin, Weigen Lu, Jianxin WangAbstractChemotherapy outcomes for the treatment of glioma remains unsatisfactory due to the inefficient drug transport across the blood‒brain barrier (BBB) and insufficient drug accumulation in the tumor region. Although many approaches, including various nanosystems, have been developed to promote the distribution of chemotherapeutics in the brain tumor, the delivery efficiency and the possible damage to the norma...
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research
In conclusion, epidemiological studies do not suggest increased brain or salivary gland tumor risk with MP use, although some uncertainty remains regarding long latency periods (>15 years), rare brain tumor subtypes, and MP usage during childhood. Expected final online publication date for the Annual Review of Public Health Volume 40 is April 1, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates. PMID: 30633716 [PubMed - as supplied by publisher]
Source: Annual Review of Public Health - Category: International Medicine & Public Health Authors: Tags: Annu Rev Public Health Source Type: research
The ischemic microenvironment in both tumor and non ‐neoplastic tissue can drive new blood vessel formation to adapt to changes in pH, oxygen tension, and restricted nutrient availability. Using neural progenitor and glioblastoma cells in an in vitro ischemic model, we demonstrated that mRNA and protein expression of the epigenetic reader CHD7 was suppressed in the ischemic microenvironment. Reducing CHD7 altered the transcriptome to increase angiogenesis‐related pathways that include CHI3L1 (YKL‐40) and increased measures of angiogenesis in vitro and in vivo. ABSTRACTTumorigenic and non ‐neoplastic tissue injury o...
Source: Stem Cells - Category: Stem Cells Authors: Tags: Cancer Stem Cells Source Type: research
Conditions:   Anatomic Stage IV Breast Cancer AJCC v8;   Astrocytoma;   Breast Carcinoma Metastatic in the Brain;   Glioma;   Invasive Breast Carcinoma;   Oligodendroglioma;   Prognostic Stage IV Breast Cancer AJCC v8;   Recurrent Glioma Interventions:   Other: Best Practice;   Drug: Ketoconazole Sponsors:   Wake Forest University Health Sciences;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Rapid advance in oncology leads to increasing survival of oncologic patients. More and more of them live long enough to reach either the natural age of menopause or, as a side effect of their oncotherapy, experience the cessation of gonadal function, leading to premature ovarian insufficiency, with disturbing vasomotor symtoms and long-term negative cardiovascular and skeletal effects. Thus, an ever increasing number of cancer survivors search endocrinologic help in the form of hormone replacement therapy (HRT). The misinterpretation of the WHI (Women's Health Initiative) Study has lead to an irrational f...
Source: Pathology Oncology Research - Category: Pathology Authors: Tags: Pathol Oncol Res Source Type: research
Cancers, Vol. 11, Pages 44: Glioblastoma’s Next Top Model: Novel Culture Systems for Brain Cancer Radiotherapy Research Cancers doi: 10.3390/cancers11010044 Authors: Seamus Caragher Anthony J. Chalmers Natividad Gomez-Roman Glioblastoma (GBM), the most common and aggressive primary brain tumor in adults, remains one of the least treatable cancers. Current standard of care—combining surgical resection, radiation, and alkylating chemotherapy—results in a median survival of only 15 months. Despite decades of investment and research into the development of new therapies, most candidate anti-glioma...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
ConclusionH3 K27M mutations are frequent in adult midline gliomas and have a prognostic role similar to H3 K27M wild-type high-grade tumors.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Abstract In recent years, we have witnessed a significant increase in the amount of studies using Mesenchymal Stem Cells (MSCs) for cancer therapy, mostly as vectors for drug or gene delivery strategies. This is because of their intrinsic capacity of homing into tumor niches. However, the interactions between MSCs themselves and tumor cells is not fully understood, with contradictory results frequently being observed regarding their effects on cancer cell invasion and proliferation. This poses an important question of safety in respect to the application of these cells. The source of the MSC population used, as we...
Source: Biochimie - Category: Biochemistry Authors: Tags: Biochimie Source Type: research
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