Genome Analysis of a Mantle Cell Lymphoma Case with t(5;18)(p15;q21) Lacking the Translocation Involving Cyclin D1

Conclusion: Our data suggested that the genes located around the breakpoint would not be related to the regulation of cyclin D1 expression in the MCL case with t(5;18), and that BRAF might contribute to the upregulation of cyclin D1.DisclosuresIida: Chugai Pharmaceutical Co., Ltd.: Research Funding. Nagai: Janssen Pharmaceutical K.K.: Honoraria, Research Funding; Abbvie G. K.: Research Funding; Bayer Yakuhin Ltd.: Research Funding; Takeda Pharmaceutical Co., Ltd.: Honoraria, Research Funding; Gilead Sciences Inc.: Honoraria, Research Funding; Zenyaku Kogyo Co., Ltd.: Honoraria, Research Funding; Solasia Pharma K.K.: Research Funding; Esai Co., Ltd.: Honoraria, Research Funding; Chugai Pharmaceutical Co., Ltd.: Honoraria, Research Funding; Mundipharma K.K.: Honoraria, Research Funding; Kyowa Hakko Kirin Co., Ltd.: Honoraria, Research Funding; Ono Pharmaceutical Co., Ltd.: Honoraria, Research Funding; Sanofi K. K.: Honoraria; Roche Ltd.: Honoraria; Otsuka Pharmaceutical Co., Ltd.: Research Funding; SymBio Pharmaceuticals Limited: Research Funding; AstraZeneca plc.: Research Funding; HUYA Bioscience International: Research Funding; Bristol-Myers Squibb: Honoraria, Research Funding; Celgene Corporation: Honoraria, Research Funding.

Source: Blood - November 21, 2018 Category: Hematology Authors: Hagiwara, K., Tokunaga, T., Iida, H., Nagai, H. Tags: 621. Lymphoma-Genetic/Epigenetic Biology Source Type: research