Donor IFNL4 Genotype Is Associated with Transplant-Related Mortality after Unrelated Donor Myeloablative Hematopoietic Cell Transplantation in Patients with Acute Leukemia

Conclusions. Donor IFNL4 genotype is associated with risk of transplant-related mortality in patients with acute leukemia. The data suggest that avoiding donors with dG/dG genotype will improve HCT outcomes without limiting the potential donor pool. A validation study is needed; if confirmed, IFNL4 genotype may provide an added value to donor selection criteria.DisclosuresLee: Onyx: Research Funding; Kadmon: Research Funding; Amgen: Consultancy, Research Funding; Mallinckrodt: Honoraria; Incyte: Consultancy; Pfizer: Consultancy; Takeda: Research Funding.

Source: Blood - November 21, 2018 Category: Hematology Authors: Gadalla, S. M., Wang, T., Onabajo, O., Wang, Y., Haagenson, M. D., Sees, J. A., Spellman, S. R., Katki, H. A., Lee, S. J., Prokunina-Olsson, L. Tags: 732. Clinical Allogeneic Transplantation: Results I Source Type: research