Progression Free Survival below 12 Months Following Stem Cell Transplant Is a Hallmark of High-Risk Myeloma Which Is Associated with Inferior Overall Survival -- Data from the Ukmrc Myeloma XI Trial

DiscussionNearly three quarters of those with PFS1<12m had died 3 years after entry to MXI, highlighting an area of urgent unmet need for this poorly understood group. Continuous lenalidomide therapy and deep serological responses did not prevent early progression in some. At 36 months post ASCT 6% of patients with PFS1<12m had not progressed for a second time compared to 33% with a PFS1≥12 months. We found 64% of patients in the short PFS group had at least one HR genetic lesion. Current standard approaches lack efficacy to salvage patients, who have been exposed to immunomodulatory drugs and proteasome inhibitors and undergo early progression, despite variation in global access to other therapies. This justifies exploration of dedicated studies to characterise these patients at baseline and develop treatments that can improve their prognosis.DisclosuresBygrave: Amgen: Honoraria; Takeda: Honoraria, Other: Travel Support; Janssen: Honoraria, Other: Travel support; Celgene: Honoraria, Other: Travel support, Research Funding. Pawlyn: Amgen: Consultancy, Honoraria, Other: Travel Support; Celgene Corporation: Consultancy, Honoraria, Other: Travel support; Takeda Oncology: Consultancy, Other: Travel support; Janssen: Honoraria, Other: Travel support. Davies: Janssen: Consultancy, Honoraria; Takeda: Consultancy, Membership on an entity's Board of Directors or advisory committees; MMRF: Honoraria; ASH: Honoraria; TRM Oncology: Honoraria; Celgene: Consultancy, Honoraria, Mem...
Source: Blood - Category: Hematology Authors: Tags: 731. Clinical Autologous Transplantation: Results: Multiple Myeloma: Upfront Autologous Transplantation Source Type: research