Blood Pressure Drug Recall Expands Again; Meds May Be Tainted With Cancer-Causing Chemical

(CNN) — The US Food and Drug Administration says another heart medicine is being voluntarily recalled after tests showed that it was tainted with a potential cancer-causing chemical. The recall includes one lot of Sandoz’s losartan potassium hydrochlorothiazide 100 milligram/25 milligram tablets with the lot number JB8912. Patients use these drugs to keep their high blood pressure in check. The drug is being recalled because the active ingredient has tested positive for N-Nitrosodiethylamine or NDEA, a suspected human and animal carcinogen that is used in gasoline as a stabilizer for industry materials and as a lubricant additive, according to the National Institutes of Health. The ingredient was made by Zhejiang Huahai Pharmaceutical Company Co. Ltd. The FDA placed the Chinese company on an import alert at the end of September, meaning all of its active pharmaceutical products and finished products will not be permitted to enter the United States. The FDA made that decision after an inspection of the facility. Several pills that contain valsartan, another drug used by heart patients, have been under a recall since July. The drugs were tainted with NDEA or NDMA, N-nitrosodimethylamine, an impurity that is also considered a possible carcinogen by the US Environmental Protection Agency. NDMA is an organic chemical used to make liquid rocket fuel and is a byproduct of manufacturing some pesticides and processing fish. It can be unintentionally introduced into manufac...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Consumer Health News Local TV Valsartan Source Type: news

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Conditions:   Non-melanoma Skin Cancer;   Melanoma;   Hypertension Interventions:   Drug: Hydrochlorothiazide;   Drug: Angiotensin-converting enzyme (ACE) inhibitors Sponsors:   Canadian Network for Observational Drug Effect Studies, CNODES;   Drug Safety and Effectiveness Network, Canada;   Canadian Institutes of Health Research (CIHR) Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
A friend of mine takes a statin medication each day to lower his cholesterol. More than once I’ve heard him say “I ate too much! I’m going to have to take an extra pill.” Never mind that it doesn’t work that way — a single additional statin pill won’t make much difference to his cholesterol or his health. And never mind that you shouldn’t self-adjust the dose of your medications (talk to your doctor before making any changes in medication dosing). But my friend’s overindulging does bring up the question of whether starting medications for conditions like high blood pres...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Exercise and Fitness Health Healthy Eating Heart Health Hypertension and Stroke Source Type: blogs
After the outbreak of the coronavirus 2019-nCov (COVID-19) in Wuhan, China, in December 2019,[1] the disease rapidly became a global pandemic. Infection rates peaked and began to decline in some Asian countries by March 2020, but Europe and the US are now among the most affected regions.[2] Most COVID-19 infections are characterized by only mild symptoms of fever and cough; however, there is a high risk of severe pulmonary infection and death, in particular for the elderly and populations with comorbidities such as diabetes, hypertension and cardiopulmonary diseases.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Source Type: research
ConclusionsTumor responses and PFS in our study were in line with other real-life clinical data and they seem to be inferior to the reported in the SELECT trial, probably related to the higher number of patients with prior MKI therapy, comorbidities, and poor performance status. Although virtually all patients experienced AEs, most of them were manageable and rarely a definitive withdrawal was necessary.
Source: Endocrine - Category: Endocrinology Source Type: research
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted. Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Bottino LG, Fuchs FD Abstract Introduction: Angiotensin receptor blockers (ARBs) are recommended as preferential drugs in the treatment of hypertension by guidelines. In this review, we reappraise their effectiveness to preventing major cardiovascular outcomes and the recent concerns with new adverse effects.Areas covered: ARBs were not superior to placebo in the prevention of all-cause deaths and combined cardiovascular events in seven randomized controlled trials (RCT). Several meta-analyses, with large number of participants, confirmed these findings. Three RCT trials, published in top journals, were re...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly. PMID: 32233181 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Update: On April 1, 2020, the FDA requested manufacturers to withdraw all prescription and over-the-counter (OTC) ranitidine drugs (Zantac, others) from the market immediately, due to the presence of a contaminant known as N-Nitrosodimethylamine (NDMA). Although the FDA did not observe unacceptable levels of NDMA in many of the samples they tested, they have determined that the impurity in some ranitidine products increases over time and when stored at higher than room temperatures. As a result of this recall, ranitidine products will no longer be available for prescription or OTC use in the US. The FDA is also advising co...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Digestive Disorders Drugs and Supplements Source Type: blogs
By now, you’ve probably heard this warning about the new coronavirus pandemic: those who are older and have a chronic medical condition are at increased risk for severe disease and death. If you fall into this category, here’s important information about the coronavirus outbreak tailored to you. If you look at the data, older adults and those with chronic health problems who get COVID-19 are more likely to require hospitalization and admission to an intensive care unit. And so far in the US, 80% of the deaths from the new coronavirus virus have occurred in people who were older. But this raises a number of ques...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Healthy Aging Infectious diseases Men's Health Prevention Women's Health Source Type: blogs
Conclusions: IDA significantly increases autoimmune disease risk, particularly in female patients and patients with certain comorbidities. Clinicians should conduct further clinical evaluations and laboratory tests of autoimmune disease in patients with IDA.Plain Language Summary: Little is known about the relationship between iron deficiency and autoimmune disease. By using a national-level database in Taiwan, we noted a meaningful association between iron deficiency anemia (IDA) and later autoimmune disease development. Our study extends the known disease range and recommends that physicians be alert for the occurrence o...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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