Clinical and laboratory profile of renal amyloidosis: A single-center experience.

Clinical and laboratory profile of renal amyloidosis: A single-center experience. Saudi J Kidney Dis Transpl. 2018 Sep-Oct;29(5):1065-1072 Authors: Engineer DP, Kute VB, Patel HV, Shah PR Abstract The kidney is the most common organ involved in systemic amyloidosis. We aimed to study etiology and clinicopathological profile of renal amyloidosis. This was a retrospective study of 40 consecutive adult patients with biopsy-proven renal amyloidosis evaluated over a period of two years. Emphasis was given to describing the clinical presentation, renal function, proteinuria, type of amyloidosis, and its etiology. Mean age of the study cohort was 44 ± 15 years (with a male-to-female ratio of 3:1). Amyloid A (AA) amyloidosis was the most common type of amyloidosis observed in 72.5% of cases. Amyloid light chain (AL) amyloidosis accounted for 17.5% of cases, and the rest remained undetermined. AA amyloidosis had widespread age distribution while AL amyloidosis was confined to those>40 years. Proteinuria was the most common renal manifestation observed in all patients. Nephrotic syndrome was seen in 70% of patients. Mean 24 h proteinuria was 6.4 g. Renal failure was the second most common manifestation seen in 70% of patients, of whom 21.4% required hemodialysis. Tuberculosis (TB) accounted for 90% cases of AA amyloidosis. The most prevalent form was pulmonary TB while the rest accounted for by rheumatoid arthritis and bronchiectasis. Among patients with...
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research

Related Links:

ConclusionsPatients with CMS were more likely to present with increased comorbidities. Patients with CMS undergoing CABG were at risk for worse short ‐term secondary postoperative outcomes and reduced long‐term survival. The data supports the need for further investigation for risk reduction surrounding operative revascularization.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractThe first successful human heart transplantation was reported on 3 December 1967, by Christiaan Barnard in South Africa. Since then this life ‐saving procedure has been performed in over 120 000 patients. A limitation to the performance of this procedure is the availability of donor hearts with as many as 20% of patients dying before a donor's heart is available for transplant. Today, hearts for transplantation are procured from indiv iduals experiencing donation after brain death (DBD). Interestingly, this, however, was not always the case as the first heart transplants occurred after circulatory dea...
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: REVIEW ARTICLE Source Type: research
CONCLUSIONS The Chinese traditional medicine compound QTF can achieve the effect of detoxification by upregulating the expression of UGT2B7 in the endoplasmic reticulum. PMID: 32061080 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
ConclusionsTransplanting kidneys from HCV-viremic donors into HCV-uninfected recipients increased quality-adjusted life expectancy and reduced costs compared with a strategy of transplanting kidneys from HCV-unexposed donors.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
As the population ages, falls are becoming one of the leading causes of morbidity and mortality. Joint disease (either osteoarthritis or rheumatoid arthritis) is a well-known predictor of falls, and these medical conditions increase in accordance with the ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Conditions:   Sleep;   Multiple Myeloma Interventions:   Behavioral: Mindfulness Awareness Practices for Insomnia;   Behavioral: Sleep Health Information Sponsor:   Medical College of Wisconsin Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Anemia, Iron Deficiency Interventions:   Other: Nutritional Education;   Other: model nutrition kitchen;   Other: recipe book;   Other: Provision of Dates Sponsors:   National Research Center, Egypt;   Taibah University;   Rotary club of Heliopolis Sporting, Egypt;   Australian Embassy of Egypt;   Sustainable Development Project in the Kingdom of Saudi Arabia (KSA) Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Vitiligo Interventions:   Procedure: Melanocyte-Keratinocyte Transplantation and Ultraviolet Lamp (UVA);   Device: RECELL 1:5 and Ultraviolet Lamp (UVA);   Device: RECELL 1:10 and Ultraviolet Lamp (UVA);   Device: RECELL 1:20 and Ultraviolet Lamp (UVA) Sponsor:   Avita Medical Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Tuberculosis;   Tuberculosis Infection Interventions:   Other: Multiple blood samples;   Other: Single blood sample Sponsor:   Hospices Civils de Lyon Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractIn a rapidly expanding population of patients with chronic kidney disease, including 2 million people requiring renal replacement therapy, cardiovascular mortality is 15 times greater than the general population. In addition to traditional cardiovascular risk factors, more poorly defined risks related to uraemia and it ’s treatments appear to contribute to this exaggerated risk. In this context, the microcirculation may play an important early role in cardiovascular disease associated with chronic kidney disease. Experimentally the uraemic environment and dialysis have been linked to multiple pathways causing...
Source: Microcirculation - Category: Research Authors: Tags: REVIEW Source Type: research
More News: Amyloidosis | Arthritis | Dialysis | Hemodialysis | Kidney Transplant | Kidney Transplantation | Laboratory Medicine | Middle East Health | Nephrotic Syndrome | Proteinuria | Renal Failure | Rheumatoid Arthritis | Rheumatology | Saudi Arabia Health | Study | Transplants | Tuberculosis | Urology & Nephrology