What Causes Hyponatremia?
Discussion Normal kidneys regulate water balance to maintain a plasma osmolality of 275-290 mOsm/kg normally. Thirst and arginine vasopressin or antidiuretic hormone (ADH) are the primary regulators of plasma osmolality. ADH is made in the hypothalamus and released by the posterior pituitary gland. ADH acts on the kidney’s distal collecting duct to increase water reabsorption. ADH is appropriately released in hypovolemic states, such as dehydration caused by gastroenteritis. ADH has an ~10 minute half-life and therefore can respond to rapid changes in volume status. Sodium balance is regulated by aldosterone (as part...
Source: PediatricEducation.org - April 23, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Researchers identify the types of genetic mutations associated with nephrotic syndrome
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) By analyzing the most common genetic variants, Brazilian scientists aim at improving diagnosis nad treatment for the disease, which presents high resistance to drugs as well as relapse in post-transplant scenario. The work made possible an in-depth study of the proteins involved in the glomerular filtration barrier, a structure which is damaged by the syndrome. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 28, 2018 Category: Biology Source Type: news
Isolated Right Ventricular Thrombus in Nephrotic Syndrome Isolated Right Ventricular Thrombus in Nephrotic Syndrome
Venous thrombosis in nephrotic syndrome is common, but in this case it occurred in an uncommon location--and was initially misdiagnosed.Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 8, 2018 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news
Genetic Testing Using a SRNS Gene Panel Genetic Testing Using a SRNS Gene Panel
The authors developed a targeted next-generation sequencing gene panel assay for diagnostic testing in steroid-resistant nephrotic syndrome or suspected Alport syndrome.Journal of Medical Genetics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 15, 2017 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news
Doncaster boy has a condition that makes him look pregnant
Mckenzie Watson, five, suffers from nephrotic syndrome, which causes his kidneys to leak, filling his abdomen with fluid. The schoolboy, from Doncaster, is left in agony as his face and belly swell. (Source: the Mail online | Health)
Source: the Mail online | Health - September 12, 2017 Category: Consumer Health News Source Type: news
Liver condition causes boy's face to swell like balloon
Mckenzie Watson, from Doncaster, was diagnosed with nephrotic syndrome which causes his kidneys to function improperly and water to build up in the body. His family are fundraising to fund a cure. (Source: the Mail online | Health)
Source: the Mail online | Health - August 22, 2017 Category: Consumer Health News Source Type: news
WATCH: Woman donates kidney to her 2-year-old granddaughter
Carol Graydon, 62, was a perfect match for Wryn Graydon, who has congenital nephrotic syndrome. (Source: ABC News: Health)
Source: ABC News: Health - July 20, 2017 Category: Consumer Health News Tags: Health Source Type: news
Nephrotic Syndrome Reported With Everolimus, Voriconazole
Case report of patient with relapsed Hodgkin's lymphoma treated with everolimus for five years (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - July 7, 2017 Category: Cancer & Oncology Tags: Nephrology, Oncology, Pharmacy, Journal, Source Type: news
Nephrotic syndrome after scorpion sting - Boju SL, Mogili HKR, Ram R, Vishnubotla SK.
Scorpion venom is a water soluble, antigenic and heterogeneous mixture. The venom is composed of varying concentration of neurotoxin, cardiotoxin, nephrotoxin, haemolytic toxin, phosphodiesterase, phospholipases, hyaluronidases, glycosaminoglycans, histami... (Source: SafetyLit)
Source: SafetyLit - May 19, 2017 Category: International Medicine & Public Health Tags: Non-Human Animals and Insects Source Type: news
Your NEJM Group Today: Nephrotic Syndrome Clinical Pearls / Tranexamic Acid for Postpartum Hemorrhage / Washington Family Medicine Opportunity (FREE)
By the Editors Here's what we chose for you from NEJM Group today:NEJM Resident 360: Clinical Pearls: What are … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - May 4, 2017 Category: Primary Care Source Type: news
Drosophila effectively models human genes responsible for genetic kidney diseases
The majority of genes associated with nephrotic syndrome (NS) in humans also play pivotal roles in Drosophila renal function, a conservation of function across species that validates transgenic flies as ideal pre-clinical models to improve understanding of human disease, a research team reports. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 17, 2017 Category: Science Source Type: news
Drosophila effectively models human genes responsible for genetic kidney diseases
(Children's National Health System) The majority of genes associated with nephrotic syndrome (NS) in humans also play pivotal roles in Drosophila renal function, a conservation of function across species that validates transgenic flies as ideal pre-clinical models to improve understanding of human disease, a Children's National Health System research team reports in a recent issue of Human Molecular Genetics. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 17, 2017 Category: Global & Universal Source Type: news
Genetics Home Reference: congenital nephrotic syndrome
https://ghr.nlm.nih.gov/condition/congenital-nephrotic-syndrome (Source: NLM General Announcements)
Source: NLM General Announcements - August 2, 2016 Category: Databases & Libraries Source Type: news
World Kidney Day 2016
10 March 2016 is World Kidney Day - a day to raise awareness of the importance of our kidneys to our overall health and to reduce the frequency and impact of kidney disease and its associated health problems worldwide. This year’s theme is ‘Kidney Disease & Children. Act Early to Prevent It!’Cochrane Kidney and Transplant (CKT) is concerned with the evaluation of care relevant to patients with kidney disease and the means of managing problems associated with interventions (chronic care, prevention, treatment, rehabilitation, and side effects of medication). They have gathered a variety of Cochrane res...
Source: Cochrane News and Events - March 9, 2016 Category: Information Technology Authors: mumoquit at cochrane.org Source Type: news
Translating research into care
Updated Cochrane Review from Cochrane Kidney and Transplat Group is making an impact in care.‘It’s not every day we get to see the immediate clinical translation of our research into care for our next patient,’ says Jonathan Craig, Coordinating Editor of the Cochrane Kidney and Transplant Group. ‘Which makes it quite striking and genuinely pleasing when we are able to do so. In the case of a recent review update, we’re seeing first hand how our findings can directly translate into greater certainty and better outcomes.’Published in March 2015, the updated Corticosteroid therapy for...
Source: Cochrane News and Events - January 28, 2016 Category: Information Technology Authors: mumoquit at cochrane.org Source Type: news
When Ayden met Aubrey: Kidney transplant creates a powerful bond between toddlers
Photos by Katherine C. Cohen Theirs is a friendship nurtured by coloring books, built on board games and mad dashes down corridors — but also silently strengthened by nature of a mutual struggle. Three-year-old Ayden Mosher of New York and 2-year-old Aubrey Ferrell of Tennessee met this fall in a lab at Boston Children’s Hospital. It was friendship at first sight. “They were just drawn to each other, and they have been inseparable ever since,” says Aubrey’s mom Janna Ferrell. Aubrey’s story Aubrey was diagnosed with congenital nephrotic syndrome at 4 months old. By 18 months, both kidne...
Source: Thrive, Children's Hospital Boston - January 7, 2016 Category: Pediatrics Authors: Emily Williams Tags: Diseases & Conditions Our Patients’ Stories kidney kidney transplant Pediatric Transplant Center (PTC) Source Type: news
In their own words: Six families share the impact of organ donation
This is the season for gratitude and giving, a time to celebrate friends, family, the end of one year and the beginning of a new one. But for a select group, it also is a time to celebrate one of the greatest gifts — the gift of life through organ donation. Mickey was born with a unique combination of congenital heart defects and spent most of his early life at Boston Children’s. He was one day shy of 6 months old when he received his heart transplant, and his family is grateful for every day since. “Mickey has shown us what courage and resiliency look like, and his transplant has taught us the true mean...
Source: Thrive, Children's Hospital Boston - January 5, 2016 Category: Pediatrics Authors: Michelle Higginson Tags: Diseases & Conditions Our Patients’ Stories double lung transplant heart transplant hepatoblastoma kidney transplant Liver transplant multivisceral transplant Pediatric Transplant Center (PTC) Source Type: news
Clinical Aspects of WT1 and the Kidney
For more than 30 years, WT1 mutations have been associated with complex developmental syndromes involving the kidney. Acting as a transcription factor, WT1 is expressed throughout the nephron and controls the reciprocal interactions and phenotypic changes required for normal renal development. In the adult, WT1 expression remains extremely high in the renal podocyte, and at a lower level in the parietal epithelial cells. Wt1-null mice are unable to form kidneys . Unsurprisingly, WT1 mutations lead to significant abnormalities of the renal and genitourinary tract, causing a number of human diseases including syndromes su...
Source: Springer protocols feed by Cancer Research - December 31, 2015 Category: Cancer & Oncology Source Type: news
How Terrified Should We Be?
After every terrorist attack we go through a period of overwhelming fear that we will individually be the target of terrorism. Recently a man told me that he will avoid going to crowded areas of the city because he fears being killed by a terrorist. A woman fears flying because she fears the plane will be blown up by a terrorist. Years ago, after 9/11, a woman told me that she feared "Arab-looking men" in the subway. And, after 9/11, years ago, a family moved to Colorado from New York City because of their fear of terrorism. Fear pervaded the lives of many people and, once again, after the attack in San Bernardin...
Source: Healthy Living - The Huffington Post - December 23, 2015 Category: Consumer Health News Source Type: news
Your NEJM Group Today: Nephrotic Syndrome Clinical Pearls, HIV & Cancer, NY Family Medicine Opportunities (FREE)
By the Editors NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today:Now@NEJM: Clinical … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - October 7, 2015 Category: Primary Care Source Type: news
The Most Unusual Deaths By State, In One Map
What are the most distinctive deaths by state? Researcher Francis Boscoe of the New York State Cancer Registry set out to answer that question by analyzing the deaths in each state from 2001 to 2010. Out of a total 136 causes of death, Boscoe pinpointed the number one reason people in different states died that was distinct from the United States’ general population. Now keep in mind that these aren’t the most common deaths in each state. Instead, think of these deaths as the ones that a state had in a disproportionately high number compared to the national average. The map, Boscoe explained, is a good way...
Source: Science - The Huffington Post - May 19, 2015 Category: Science Source Type: news
Outlook Favorable in Relapsing Nephrotic SyndromeOutlook Favorable in Relapsing Nephrotic Syndrome
Children with frequently relapsing nephrotic syndrome (FRNS) have favorable overall survival and renal function, despite their high relapse rate, Japanese researchers say. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 17, 2014 Category: Consumer Health News Tags: Nephrology News Source Type: news
A 28-gene test for kidney disease
We report and comment on medical innovations and advances – from bench to bedside – touching on scientific, business and policy issues. Our ranks include science writers, physicians, lab researchers, market analysts and others inside and outside the hospital. Understanding the genetic causes of nephrotic syndrome could lead to better drug treatments that reduce the need for dialysis or a kidney transplant. (Image: Wikimedia Commons) By Nancy Fliesler News Well, Vector Blog, Big Data, Blogread more (Source: Mass Device)
Source: Mass Device - September 15, 2014 Category: Medical Equipment Authors: MassDevice Tags: Vector Blog Source Type: news
What Causes Proteinuria?
Discussion Proteinuria occurs relatively often in pediatric practice with 5-15% of school children having transient proteinuria, the most common cause. However, proteinuria can be a sign of kidney disease. Therefore, it is important to evaluate the proteinuria in light of the clinical situation. A good history and physical examination along with a full urinalysis and/or BUN and creatinine, or urine protein/creatinine ratio may be all that is necessary. Another patient with edema, hypertension or hematuria needs a fuller evaluation and treatment. Proteinuria is usually categorized into three groups to assist with evaluation...
Source: PediatricEducation.org - August 18, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Saved by her grandma, the six-year-old girl who needed kidney after more than 30 operations
Ella Chadwick, from Manchester, was born with the rare condition congenital nephrotic syndrome, which caused both her kidneys to fail when she was 19 months old. (Source: the Mail online | Health)
Source: the Mail online | Health - May 27, 2014 Category: Consumer Health News Source Type: news
Questcor reports positive clinical trial results of Acthar in nephrotic syndrome patients
US-based biopharmaceutical firm Questcor Pharmaceuticals has reported results from an investigator-initiated clinical trial evaluating the dosing and effectiveness of HP Acthar Gel (repository corticotropin) in 20 patients with nephrotic syndrome due… (Source: Drug Development Technology)
Source: Drug Development Technology - April 22, 2014 Category: Pharmaceuticals Source Type: news
Children with glomerular kidney disease more likely to have hypertension as adults
Men who as children had glomerular disease, a disorder of the portion of the kidney that filters blood and one that usually resolves with time, were more likely than men without childhood glomerular disease to have high blood pressure as an adult, according to a study in the March 19 issue of JAMA.Glomerular disease was defined for this study as glomerulonephritis or nephrotic syndrome (both are kidney disorders). Most children who develop glomerular disease have a favorable prognosis with complete resolution of all signs and symptoms. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 20, 2014 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news
Martin Barratt obituary
Paediatric nephrologist whose research led to the improved treatment of common childhood kidney diseasesMartin Barratt, who has died aged 77 from a progressive form of muscular dystrophy, was professor of paediatric nephrology at the Institute of Child Health, London, and consultant nephrologist at Great Ormond Street Hospital for Children. He was one of the first to establish a specialist service for children with kidney diseases in Britain, developing a model of interdisciplinary care that was later adopted by many other centres throughout the world. His research led to improved understanding and treatment of many common...
Source: Guardian Unlimited Science - February 3, 2014 Category: Science Authors: Michael Levin Tags: theguardian.com Children Obituaries Medical research Hospitals NHS Science Source Type: news
Nephrotic syndrome following mercury vapor exposure
3 out of 5 stars Mercury poisoning from home gold amalgam extraction. Saleem M et al. Med J Aust 2013;199:125-127. No abstract available This case report describes a 62-year-old man who presented with flu-like symptoms and increasing shortness of breath. History revealed that he had recently attempted to extract gold from mercury-containing amalgam by heating the amalgam in a pan. As a result, he had been exposed to mercury fumes for approximately 3 hours. Workup revealed pneumonitis, as well as elevated blood and urine mercury levels. The patient was treated with chelation (DMSA) and steroids. One month later...
Source: The Poison Review - July 24, 2013 Category: Toxicology Authors: Leon Tags: Medical mercury toxicity mercury vapor nephrotic syndrome pneumonitis renal toxicity Source Type: news
RCT: Immunosuppression for progressive membranous nephropathy
Source: Lancet Area: News Membranous nephropathy is the most common cause of primary nephrotic syndrome in adults and leads to end-stage renal disease in more than 20% of patients. Although immunosuppressive therapy benefits some patients, trial evidence for the subset of patients with declining renal function is not available. The UK Renal Association Clinical Trials Committee's glomerulonephritis subgroup aimed to assess whether immunosuppression preserves renal function in patients with idiopathic membranous nephropathy with declining renal function. This trial was conducted in 37 renal units across the UK a...
Source: NeLM - News - January 10, 2013 Category: Drugs & Pharmacology Source Type: news
Extending Steroid Treatment Does Not Benefit Children With Hard-To-Treat Kidney Disease
Extending steroid treatment for the most common form of kidney disease in children provides no benefit for preventing relapses or side effects, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings challenge previous assumptions about optimal treatment strategies for this disease. Nephrotic syndrome is the most common kidney disease in childhood. Children with the disease are at risk of developing severe infections and other complications because their kidneys leak important proteins from the blood into the urine... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 2, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news