The Relationship Between Sleep and Alzheimer ’ s Disease

This study is part of a growing body of research that suggests a sleep-deprived brain might be more vulnerable to Alzheimer’s disease. Animal studies have shown levels of plaque-forming A-beta plummet during sleep. Other research points to the fact that a sleeping brain runs the “clean cycle” (a reference to a dishwasher) to remove the day’s metabolic debris, specifically A-beta plaques. A study done in 2017 found that even one sleepless night appears to leave behind an excess of the troublesome protein fragment. While this is all impressive research, scientists believe there are still plenty of gaps. Basically, there’s not enough evidence yet to know the degree to which sleep might make a difference in the disease, and study results are not consistent. A 2017 analysis of studies found that poor sleepers appeared to have approximately a 68 percent higher risk of Alzheimer’s than those who were rested. But we’re back to the chicken and egg question. What comes first? More research is needed. However, we do know that approximately one-third of American adults are sleep deprived (sleeping fewer than seven hours a night) and the number of people with Alzheimer’s disease is increasing. Certainly, a good night’s sleep could benefit us all.
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Alzheimer's Health-related Mental Health and Wellness Research Sleep Alzheimer's disease Dementia Source Type: blogs

Related Links:

Whether indigenous or introduced, red deer (Cervus elaphus,left) now roam every continent except Antarctica. Females ( “hinds”) and males (“stags” or “harts”) segregate most of the year into bachelorette and bachelor groups, respectively. In preparation for autumn battles for a harem of hinds, each hart’s antlers (right) start growing in the spring before shedding by end of winter. Harder than bone, their antlers have been fashioned by humans into knives and other tools for thousands of years. Antler carvers learned rather quickly not to discard leftover horn into campfires because...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
This study utilised 5-FU-treatment in a model of colitis-associated CRC to develop a pre-clinical setting of intestinal mucositis coincident with manifestation of CRC.Materials/methods: On day 0, female C57BL/6 mice (n = 10/group); (1) saline control, (2) AOM/DSS control, or (3) AOM/DSS + 5-FU were injected with saline or AOM (i.p; 7.4 mg/kg). Groups 2 and 3 underwent cycles of seven days 2%w/v DSS followed by 14 days plain water. After three cycles, 5-FU was administered weekly (i.p; 75 mg/kg) to group 3 for five weeks. Clinical indicators were measured daily and colonoscopy performed at...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Conclusion: Our study demonstrated the urgent need for improved liver screening, health education regarding risk behavior and improved awareness campaigns on liver disease. Interest of the general population may be presumed as more than 200,000 people accessed our test of their own accord. PMID: 31822163 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
This study was designed to investigate characteristics of the disease to predict recurrence.Methods: We retrospectively analyzed 617 patients that experienced a first AP attack between January 2009 and December 2014. Based on reviews of clinical and follow-up data, we attempted to identify risk factors of recurrence using Cox regression analysis.Results: During a median follow-up of 3.2 years (range 3-72 months), 100(16.2%) of the 617 study subjects experienced one or more episodes of recurrent acute pancreatitis (RAP). Of these 100 patients, 75(75%) experienced one relapse, 12(12%) two relapses, and 13(13%) ...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Publication date: Available online 11 December 2019Source: Progress in Natural Science: Materials InternationalAuthor(s): Yanan Yu, Miaomiao Zhai, Jingbo HuAbstractBimetallic Ni and Ti nanoparticle-modified indium tin oxide electrode (Ni–Ti NPs/ITO) were prepared by a two-step ion implantation method, and their electrocatalytic activity toward the oxidation of ethanol and glycol was evaluated. The ion-implantation method is simple, low-cost and environmental friendly without the use of any binder. The Ni–Ti NPs/ITO electrode were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM)...
Source: Progress in Natural Science: Materials International - Category: Materials Science Source Type: research
My grandfather was a true Yankee farmer. Taciturn and dignified, he rarely said a paragraph when a few words would do. Once, when I was in my mid-twenties and totally clueless about what it means to be dealing with old age, I found him sitting at the kitchen table translating poetry from German to English. Then in his late 70s, it had been over 50 years since he took basic German at the agricultural college he attended. I didn’t have any idea he knew even one German phrase. Yet there he was, diligently working out the poem, word by word by word. “Why don’t you just get an English translation?” I as...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Health-related Memory and Perception Self-Help Cognitive Function Memory Loss Source Type: blogs
This study is the clearest demonstration in humans that sleep disruption leads to an increased risk of Alzheimer’s disease through an amyloid beta mechanism,” said senior author Randall Bateman, MD, the Charles F. and Joanne Knight Distinguished Professor of Neurology. “The study showed that it was due to overproduction of amyloid beta during sleep deprivation.”More than 5 million Americans are living with Alzheimer ’s, a disease characterized by gradual memory loss and cognitive decline.What is the Difference Between Alzheimer ’s and DementiaThis study indicatesthat sleeping poorly...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: health lack of sleep alzheimer's lack of sleep dementia poor sleep linked to alzheimer Source Type: blogs
It’s amazing how a good night’s sleep can rejuvenate the mind, or “rest the little grey cells” as Hercule Poirot, Agatha Christie’s famed sleuth, liked to say. But sound slumber may boost the brain another way by protecting you against Alzheimer’s disease. Research has begun to show an association between poor sleep and a higher risk of accumulating beta-amyloid protein plaque in the brain, one of the hallmarks of the disease. “Observational studies have found that adults over age 65 with amyloid plaques in their brain have reduced slow-wave sleep, which is thought to play an impor...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Alzheimer's Disease Behavioral Health Brain and cognitive health Healthy Aging Memory Sleep Source Type: blogs
This article was originally published on Recovery Brands' Pro Talk/Pro Corner http://www.rehabs.com/pro-talk-articles/yes-benzos-are-bad-for-you/ Allen Frances is a professor emeritus at Duke University and was the chairman of the DSM-IV task force. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Science - The Huffington Post - Category: Science Source Type: news
By Brandon R. Peters, M.D. The news was enough to give you indigestion: Some of the over-the-counter and prescription medications most widely used to treat heartburn and acid reflux are linked to the development of dementia. The research suggesting a possible association is the latest in a string of implicated drugs over the past few years, including medications taken to treat anxiety, seizures, insomnia, and allergies. What is going on? Before emptying out the medicine cabinet, take a moment to consider the role of untreated obstructive sleep apnea. Scientific research can be difficulty to contextualize, especially when i...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
More News: Alzheimer's | Amnesia | Brain | Dementia | Insomnia | Men | Neurology | Neuroscience | PET Scan | Psychology | Science | Sleep Disorders | Sleep Medicine | Study