Perioperative Heart-Brain Axis Protection in Obese Surgical Patients: the Nutrigenomic Approach.

Perioperative Heart-Brain Axis Protection in Obese Surgical Patients: the Nutrigenomic Approach. Curr Med Chem. 2018 Oct 15;: Authors: Agrimi J, Baroni C, Anakor E, Lionetti V Abstract The number of obese patients undergoing cardiac and non cardiac surgery is rapidly increasing because they are more prone to concomitant diseases, such as diabetes, thrombosis, sleep-disordered breathing, cardiovascular and cerebrovascular diseases. Even if guidelines are already available to manage anesthesia and surgery of obese patients, the assessment of the perioperative morbidity and mortality from heart and brain disorders in morbidly obese surgical patients will be challenging in the next years. The present review will recapitulate the new mechanisms underlying the heart-brain axis vulnerability during the perioperative period in morbidly obese patients. Finally, we will describe the nutrigenomic approach, an emerging noninvasive dietary tool, to maintain an healthy body weight and to minimize the heart-brain axis propensity to injury in obese individuals undergoing all types of surgery by personalized intake of plant compounds affecting the switch from health to disease in an epigenetic manner. PMID: 30324875 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research