Blood-Brain Barrier: From Physiology to Disease and Back.
Blood-Brain Barrier: From Physiology to Disease and Back. Physiol Rev. 2019 Jan 01;99(1):21-78 Authors: Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV Abstract The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and pathogens from entering the brain. At the same time, the BBB regulates transport of molecules into and out of the central nervous system (CNS), which maintains tightly controlled chemical composition of the neuronal milieu that is required for proper neuronal functioning. In this review, we first examine molecular and cellular mechanisms underlying the establishment of the BBB. Then, we focus on BBB transport physiology, endothelial and pericyte transporters, and perivascular and paravascular transport. Next, we discuss rare human monogenic neurological disorders with the primary genetic defect in BBB-associated cells demonstrating the link between BBB breakdown and neurodegeneration. Then, we review the effects of genes underlying inheritance and/or increased susceptibility for Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease, and amyotrophic lateral sclerosis (ALS) on BBB in relation to other pathologies and neurological deficits. We next examine how BBB dysfunction relates to neurological deficits and other pathologies in the majority of sporadic AD, PD, and ALS cases, multiple sclerosis, other neurodegenerative disorders, and acute CNS disorders such as stroke, traumatic brain ...
Publication date: Available online 31 March 2020Source: Journal of Sound and VibrationAuthor(s): Ge Yan, Hong-Xiang Zou, Sen Wang, Lin-Chuan Zhao, Qiu-Hua Gao, Ting Tan, Wen-Ming Zhang
Authors: Matsumura E, Nohara K, Tanaka N, Fujii N, Sakai T Abstract Polypharmacy in elderly persons living at home or in a nursing home is an issue. In the field of dentistry, strategies to reduce polypharmacy must be promoted; however, there is insufficient basic data on medications received by elderly persons with dysphagia living at home or in a nursing home. The subjects were 106 elderly persons with dysphagia living at home or in a nursing home. Based on their medical records, the presence of disease and number/type of drugs being administered were investigated. Stroke, dementia, and hypertension were common. ...
Publication date: Available online 31 March 2020Source: Neurología (English Edition)Author(s): L.A. Rodríguez de Antonio, I. García Castañón, M.J. Aguilar-Amat Prior, I. Puertas, I. González Suárez, C. Oreja Guevara
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Publication date: Available online 31 March 2020Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Razieh Amini, Sajad karampoor, Hamid Zahednasab, Hossein Keyvani, Masoud Gheiasian, Farid Azizi Jalilian
Doctors have observed neurological symptoms, including confusion, stroke and seizures, in a small subset of Covid-19 patients.
Publication date: Available online 31 March 2020Source: Neurophysiologie CliniqueAuthor(s): Karim Jamal, Stéphanie Leplaideur, Chloé Rousseau, Sébastien Cordillet, Annelise Moulinet Raillon, Simon Butet, Armel Cretual, Isabelle Bonan
Publication date: Available online 31 March 2020Source: Neuroscience LettersAuthor(s): Zhongjie Zhou, Bowen Hu, Qiunan Lyu, Tianhang Xie, Juehan Wang, Qianyun Cai
WEDNESDAY, April 1, 2020 -- Telephone-based cognitive behavioral therapy (T-CBT) seems to be an effective intervention for depression in Parkinson disease (PD), outperforming treatment-as-usual (TAU) on all depression, anxiety, and quality-of-life...