Moderate-intensity exercise and renin angiotensin system blockade improve the renovascular hypertension (2K1C)-induced gastric dysmotility in rats

Publication date: Available online 28 August 2018Source: Life SciencesAuthor(s): Erick Bryan de Sousa Lima, Lúcia Castro Santos de Oliveira, Geovane da Silva Cardoso, Pedro Victor Nogueira Teles, Lara da Costa Lima, Jessica Fernanda Reis e Sousa, Ruan Pablo Nunes Araújo, Aldeideia Pereira de Oliveira, Rosimeire Ferreira dos Santos, Armenio Aguiar dos Santos, Moisés Tolentino Bento da SilvaAbstractActually, arterial hypertension is a major public health concern, which involves the renin angiotensin aldosterone system (RAS), via activation of the angiotensin receptors AT1 and AT2 of the cardiovascular system. Although angiotensin is an important stimulant of the gut permeability to sodium and water, little is known about the effects of arterial hypertension on gut motor behavior. Thus, we evaluated in rats the effect of hypertension induced by two-kidney one-clip (2K1C) model on the gastric motility, as well as the influence of exercise and RAS blockers treatment in such phenomenon. One week after surgery the rats were treated with Aliskiren (50 mg·kg−1, p.o.), Captopril (50 mg·kg−1, p.o.) or Losartan (10 mg·kg−1, p.o). Other group of rats was submitted to swimming with 5% body weight overload. After 4 weeks of physical training or pharmacological treatment, we assessed the gastric retention in all groups (GR) of a liquid test meal, the mean arterial pressure (MAP), the heart rate (HR) and the HR variation (HRV) as well as the in vitro contractility of gastr...
Source: Life Sciences - Category: Biology Source Type: research