New therapy spurs nerve fibers to regrow through scar tissue, transmit signals after spinal cord injury in rodents

Neuroscientists at UCLA, Harvard University and the Swiss Federal Institute of Technology have identified a three-pronged treatment that triggers axons — the tiny fibers that link nerve cells and enable them to communicate — to regrow after spinal cord injury in rodents. Not only did the axons grow through scars, they could also transmit signals across the damaged tissue.If researchers can produce similar results in human studies,  the findings could lead to a therapy to regrow axon connections in  people living with spinal cord injury, potentially restoring function. Nature publishes the research in its Aug. 29 online edition.“The idea was to deliver a sequence of three very different treatments and test whether the combination could stimulate disconnected axons to regrow across the scar in the injured spinal cord,” said lead author Michael Sofroniew, a professor of  neurobiology  at the  David Geffen School of Medicine at UCLA. “Previous studies had tested each of the three treatments separately, but never together. The combination proved to be the key.”When people injure their spinal cords, it damages the axons and prevents the brain from sending signals to neurons below the injury site. This leads to paralysis and the loss of other neurological functions, such as bladder control and hand strength. The UCLA approach could provide the first step to solving this problem.According to Sofroniew, many decade...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Bioness, a Valencia, California medical device/rehabilitation company, recently received approval from Health Canada for its StimRouter device, an implantable peripheral nerve stimulator designed to reduce chronic pain. We spoke with Mark Geiger, the...
Source: Medgadget - Category: Medical Devices Authors: Tags: Anesthesiology Exclusive Neurosurgery Pain Management Source Type: blogs
Central neuropathic pain, which is pain caused by a lesion or disease of the central somatosensory nervous system, is a serious consequence of spinal cord injury, stroke, multiple sclerosis and other conditions affecting the central nervous system. A collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership and the American Pain Society (APS), the ACTTION-APS Pain Taxonomy (AAPT) initiative, invited a working group to develop diagnostic criteria for central neuropathic pain.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
CONCLUSIONS: Inadvertent lumbar dural punctures led to multiple neurological complications including intracranial hypotension, subdural hematomas, and double vision/6(th) cranial nerve palsies. Uniquely, inadvertent cervical dural punctures solely due to CESI directly resulted in intramedullary spinal cord injuries or cord stroked and monoplegia/quadriplegia attributed to intravascular/vertebral artery injections. The potential neurological risks/complications/adverse events attributed to lumbar and cervical ESI must be taken into account before spine surgeons and others order these procedures. PMID: 28540126 [PubMed - in process]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Conclusions:This ongoing study suggests that patients with low mean minimal pulsatility index had poor functional outcomes relative to patients that had higher mean pulsatility index.Study Supported by: This work was supported in part by a grant from the McKnight Brain Research Foundation, Brain and Spinal Cord Injury Research Trust Fund, a grant from NIH National Institute of Neurological Disorders and Stroke, a Medical Student Anesthesia Research Fellowship awarded by the Foundation for Anesthesiology Education and Research, a grant from the Medical Student Research Program at the University of Florida, and the Departmen...
Source: Neurology - Category: Neurology Authors: Tags: Subarachnoid Hemorrhage, Intracranial Aneurysm, and Other Cerebrovascular Malformations Source Type: research
Neurological injury is a major limitation of aortic surgery, whether it involves spinal cord injury following intervention to the thoracoabdmoinal aorta, or stroke following surgery on the arch and ascending aorta. Despite an extensive body of literature and various proposals, a completely effective strategy to prevent or treat neurological injury remains elusive. In this article we summarise the evidence for established and emerging strategies, as well as review current concepts in pathophysiology and risk assessment as they relate to neurological injury.
Source: Best Practice and Research. Clinical Anaesthesiology - Category: Anesthesiology Authors: Source Type: research
More and more people are seeking injections of anti-inflammatory steroid medications for back and neck pain. In 2011, the last year for which complete information is available, doctors pushed the plunger on 2.3 million steroid injections into the spine — and that’s just among people covered by Medicare. These injections deliver drugs that mimic the effects of two hormones, cortisone and hydrocortisone, to reduce inflammation and help relieve pain. When they work — they don’t always — such injections can bring profound relief. “If you are in severe pain with a ruptured spinal disc and you...
Source: New Harvard Health Information - Category: Consumer Health News Authors: Tags: Back Pain Drugs and Supplements anti-inflammatory steroid medications spinal injections spine steroid injections Source Type: news
NEUROLOGIC INJURY can be defined as any temporary or permanent injury to the central and peripheral nervous system, including the brain, spinal cord, and peripheral nerves. This is a major perioperative complication of cardiac and aortic surgery, which can manifest as short-term coma or a state of confusion and long-term decline in cognitive function, behavioral changes, or physical dysfunction. Stroke occurs in approximately 2% to 3% of adult cardiac surgery patients. The rate of postoperative cognitive decline is less clear, due to heterogenous testing methods, but is reported in 50% to 70% of patients at 1 week, 30% to ...
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Review Article Source Type: research
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